MOA: opioid STRONG agonist used for strong analgesia, has a rapid onset, short duration (15-30 mins)
Codeine
MOA: weak mu receptor agonist, weak for analgesia often used in combo w/ ASA or acetaminophen, low abuse potential b/c causes less euphoria than morphine
MOA: acetylated morphine due to acetylation able to cross BBB w/ ease = 3x more potent than morphine, causes extreme euphoria
Pentazocine
MOA: opiate used foragonal & antagonal effects on differing receptors, analgesic less so than morphine; ADRs: potent dysphoria-inducing drug, @ high doses + respiratory depression, decreased GI activity, HPTN, hallucinations, nightmares, tachy & dizziness
Kappa receptor
analgesia, sedation/dysphoria, pupil constriction
Naloxone
MOA: displaces all receptor-bound opiate molecules, reverses opiate OD w/in 30 secs
Methadone
MOA: STRONG opioid agonist, equal potency to morphine, but has longer duration of action = good tx from opioid w/drawl, greatest effect on the mu receptor
