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absite infxn

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Question
Answer
what pathogens are in stomach? How many?   virtually sterile, some GPC and yeast  
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what pathogens are in sm bowel? How many?   10^5, mostly GPCs  
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what pathogens are in distal sm bowel? How many?   10^7, GPCs, GPR, GPCs  
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what pathogens are in colon? How many?   10^11, almost all anaerobes, some GNRs, GPCs  
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MC anaerobe GI   Bacteroides fragilis  
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MC aerobe in GI   e coli  
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MC GN sepsis   E coli  
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name toxins in E coli sepsis   Endotoxin lipopolysacc lipid A released, triggers TNF from macrophages->complement and coag cascade  
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what happens to blood glucose before/during sepsis   incrsd, at first due to impaired utilization, then due to insulin resistance  
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when do abscesses appear   7-10 d s/p surgery  
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types of bac in abscesses   all have anaerobe, 80% have aerobes  
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tx abscess   drainage, but add Abx if DM, cellulitis, bioprosthetic implants, s/s sepsis, F, WBC  
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rate of wound infxn clean surgery, ex   hernia, 2%  
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rate of wound infxn clean contaminated, ex   elective colon resxn w prep, 5%  
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rate of wound infxn contaminated surgery, ex   gun shot bowel, 5-10%  
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rate of wound infxn grossly contaminated surgery, ex   abscess, 30%  
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MC organism in surgical wound   S aureus  
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MC GNR in surgical wound infxn   E Coli  
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MC non surgical infxn s/p surgery   UTI  
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3 MC organism line infxn   Staph Epi, #2 S aureus, #3 yeast  
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how many CFU mean line infxn   15  
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when can necrotizing fascitis appear   within hrs s/p surgery  
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MC causes nec fascitis   Grp A strep (Strep Pyo), C perfringens  
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what 3 grps at risk for nec fasc   DM, immunocomp, poor blood supply  
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what lab work see in nec fascitis   WBC>20, hypoNa  
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key findings physical exam nec fascitis   thin gray drainage, edema, skin blistering/sloughing, crepitus/soft tissue gas,  
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tx nec fascitis   debridement and PCN  
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what's fournier's gangrene, what pts get it, and what organisms   perineal and scrotal area in DM and immunocompromised. Mixed organisms  
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is nocardia a fungus? Tx?   no, bactrim  
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where is histo found? Cocci? Tx?   histo in Mississippi and Ohio river valleys, tx both amph for severe infxn  
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tx candida   flucanazole, amph for severe  
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where does cryptococc infect? Tx?   neuro (meningitis), amph for severe [remember cryptospor is parasite causing diarrhea]  
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diagnosis for SBP   500PMN/cc (another place says 250); note cx often negative  
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if monobac what SBP 2 org MC?   E Coli, Strep  
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tx SBP   ceftriax  
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ppx SBP   fluoroquin  
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if SBP not improving on Abx, then   think intrabd source, ie perf diverticular abscess  
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what's 2ry SBP, organisms   intrabd source (transmucosal migration, perf as opposed to decrsd host defense); polymicrob (B Fragilis, E Coli, Enterococc)  
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risk HIV transmission if + blood transfusion? + mother? Needle stick?   70%, 30%, 0.3%  
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what give for HIV exposure and when   AZT, lamivudine 1-2 hrs  
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seroconversion in HIV   6-12wks  
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MC cause GI complaints HIV   CMV colitis  
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where does lymphoma appear in HIV, MC type and tx   stomach, B cell NHL, tx w chemo  
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is upper or lower GI bldg more common in HIV   lower  
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MC 2 causes upper GI bleeding in HIV   Kaposi, lymphoma  
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MC 3 causes lower GI bleeding hiV   CMV, bac, HSV  
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how commonly does HepC become chronic   60%  
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how often does cirrhosis develop in hep C over how long; what can help prevent that   15% over 20yrs; IFN  
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how often HCC in HepC   1-5%  
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tx for brown recluse spider bite   dapsone  
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3 MC organisms septic joint   Gono, Staph, H Flu  
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empiric tx septic joint until cx   Cephalo and vanc until cx  
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organisms in DM foot infxns   mixed: staph, strep, GNR, anaerobe  
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tx DM foot infxn   Unasyn, Zosyn  
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organism in cat/dog bite, tx   Pasteurella multocida, augmentin  
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organism in human bite, tx   Eikenella, augmentin  
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bug for impetigo, erysipelas, cellulitis, folliculits   Staph, strep  
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bug in furuncle, tx   Staph Epi or Staph Aureus, drain and Abx  
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2 MC bug in peritoneal dialysis cath infxn   Staph Epi or Aureus, can also be fungal which is hard to tx  
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tx peritoneal dialysis cath infxn   intraperitoneal vanc and gen  
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