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Top 200 #3

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Class
Brand
Generic
Indications
Dose Forms
Route
Adult/Ped. Dosing
MOA
K+ Sparing Diuretic/Thiazide Combo   Dyazide (capsule); Maxzide (tablet)   Triamterene/ Hydrochlorothiazide   HTN, Edema   Tablet (Maxzide): 37.5/25 or 75/50mg Capsule (Dyazide): 37.5/25 or 50/25mg   Oral   Triamterene: 37.5-75mg QD HCTZ: 25-50mg QD Ped:N/A   show
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Diuretic   Lasix   Furosemide   HTN, Edema   show Oral, IV, IM   20-80mg TID-QID Ped: 1-2mg/kg/day   Anthanilic acid derivative and a potent diuretic that works by blocking the absorption of Na+ and Cl- in the kidney tubules, causing a profound increase in urine output  
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ACE Inhibitor/ Thiazide Combo   Prinzide; Zestoretic   Lisinopril/ Hydrochlorothiazide   HTN   show Oral   10/6.25 – 80/50mg QD Ped:N/A   diuretic and an antihypertensive agent that lowers elevated blood pressure; ACE inhibitor  
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ACE Inhibitor/ Ca2+ Channel Blocker   Lotrel   Amlodipine/ Benazepril   HTN   Capsules: 2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40mg   show 2.5/10-10/40mg QD Ped:N/A   Amlodipine: dihydropyridine Ca2+ channel blocker Benazepril: nonsulfhydryl ACE inhibitor  
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Beta-Adrenergic Blocker/Thiazide Combo; Cardioselective   Tenoretic   Atenolol/ Chlorthalidone   HTN   Tablets: 50/25 or 100/25mg   Oral   show Atenolol: beta-blocking agent Chlorthalidone: diuretic acting on the cortical diluting segment of the ascending limb of the loop of Henle; increase excretion of Na+ and Cl-  
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Anticoagulant; Factor Xa inhibitor   Xarelto   Rivaroxiban   Deep Vein Thrombosis, Pulmonary embolism, Prophylaxis, Nonvalvular atrial fibrillation   Tablets: 10, 15, 20 mg   Oral   show Rivaroxaban selectively inhibits factor Xa without the need of a cofactor (eg, anti-thrombin III) for activity.  
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Anticoagulant; Low Molecular Weight Heparin   Lovenox   Enoxaparin   show Inj. Soln.: 30mg/0.3ml, 40/0.4, 60/0.6, 80/0.8, 100mg/ml, 120/0.8, 150mg/ml   SubQ   0.75-1.5mg/kg QD (30-150mg per dose) Ped: 0.5-1.5mg/kg every 12 hours   Low molecular weight heparin with anti-Factor Xa and anti-thrombin activities  
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Anticoagulant; Thrombin Inhibitor   show Dabigatran   Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism   Capsules: 75 or 150mg   Oral   150mg BID Ped:N/A   Competitive, direct thrombin inhibitor which prevents thrombus development. It inhibits both free & clot-bound thrombin as well as thrombin-induced platelet aggregation  
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Anticoagulant   Coumadin; Jantoven   Warfarin   show Tablets: 1, 2, 2.5, 3, 4, 5, 6, 7.5, 10mg IV Powder for Soln. (Coumadin only): 5mg   Oral, IV   1-10mg QD Ped:N/A   Blocks the regeneration of vitamin K epoxide, thus inhibiting synthesis of vitamin K-dependent clotting factors (2, 7, 9 and 10) and the anticoagulant proteins C and S  
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show Plavix   Clopidogrel   Prophylaxis, Thrombosis   Tablets: 75 or 300mg   Oral   75mg QD Ped:N/A   Anticoagulant; prodrug that inhibits platelet aggregation by selectively & irreversibly binding to the ADP P2Y12 receptor on platelets  
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Parenteral Electrolyte (K+ Supplement)   K-Dur; K-Tab; Klor-Con   show Hypokalemia, Prophylaxis   K-Dur: 20 mEq ER tablet K-Tab: 10 mEq ER tablet Klor-Con: 20 or 25 mEq oral powder for soln., 8, 10, M10, M20 ER tabs   Oral, IV   10-100 mEq once to five times daily Ped: Oral: 3-8 mEq/kg/day IV: 0.5-0.75 mEq/kg over 1-2 hrs   Electrolyte replenisher that aids in many physiological processes  
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CNS Agent; Immune Suppressant   show Glatiramer acetate   Relapsing remitting Multiple Sclerosis   Inj. Soln.: 20mg/ml   SubQ   20mg QD Ped:N/A   Believed to modify immune processes or functions which are thought to be liable for MS pathogenesis. In vitro studies suggest that glatiramer specific suppressor T-cells are induced & activated in the periphery  
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Colony Stimulating Factor; Hematopoietic   show Pegfilgrastim   Febrile neutropenia in patients with non-myeloid malignancies, Prophylaxis   Inj. Soln.: 6mg/0.6ml   SubQ   6mg once per chemo cycle (don’t administer between 14 days prior to & 24 hrs after admin of chemo) Ped:N/A   A colony stimulating factor that acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional actv’n  
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show Rituxan   Rituximab   Non-Hodgkins lymphoma, Rheumatoid Arthritis, Chronic Lymphoid Leukemia   Inj. Soln.: 10mg/ml   IV   375mg/m(2), usually given as part of a scheduled regiment with other meds Ped:N/A   MAB that binds to antigen CD20, this disrupts the cell cycle of B-cells resulting in cell lysis and even apoptosis  
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show Aldactone   Spironolactone   HTN, Hypokalemia, Ascites, Edema, Aldoseronism   Tablets: 25, 50, 100mg   Oral   25-400mg QD Ped:N/A   Renal competitive aldosterone antagonist; it inhibits the effect of aldosterone by competing for the aldosterone-dependent Na+/K+ exchange site in the distal tubule cells. This increases the secretion of H2O & Na+, while decreasing the excretion of K+  
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ARB/Thiazide Combo   show Irbesartan/ Hydrochlorothiazide   HTN   Tablets: 150/12.5, 300/12.5, 300/25   Oral   150/12.5-300/25mg QD Ped:N/A   ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)  
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ARB/Thiazide Combo   Benicar HCT   Olmesartan/ Hydrochlorothiazide   show Tablets: 20/12.5, 40/12.5, 40/25mg   Oral   20/12.5-40/25mg QD Ped:N/A   ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)  
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ARB/Thiazide Combo   Diovan HCT   Valsartan/ Hydrochlorothiazide   HTN   Tablets: 80/12.5, 160/12.5, 160/25, 320/12.5, 320/25mg   show 160/12.5-320/25mg QD Ped:N/A   ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)  
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ARB/Thiazide Combo   Hyzaar   Losartan/ Hydrochlorothiazide   HTN, Prophylaxis   show Oral   50/12.5-100/25mg QD Ped:N/A   ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)  
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Diuretic; Thiazide   HCTZ   Hydrochlorothiazide   HTN, Edema   Tablets: 12.5, 25, 50mg Capsule: 12.5mg   Oral   show Electrolyte reabsorption inhibitor (resulting in increased excretion of Na+ and Cl- in equal amounts)  
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