UCI Physio Test 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| half life of thrombocytes | 5 days
🗑
|
||||
| platelet adhesion binding proteins | GPIaIIa binds collagen; GPIbIX binds von Willebrand factor; GPIIbIIIa binds fibrinogen to other platelets
🗑
|
||||
| when are GPIIbIIa receptors exposed on platelets | during activation
🗑
|
||||
| action of serotonin | vasoconstriction
🗑
|
||||
| action of ADP | activates other platelets
🗑
|
||||
| pathway of which COX 1 is part | phospholipid (phospholipase A2) arachodonic acid (COX1) prostoglandin H2 (thromboxane synthase) thromboxane A2 which activates other platelets
🗑
|
||||
| pathway of which COX 2 is part | arachidonic acid (COX2) prostaglandin G2 (protocyclin synthase [PGI]) prostocyclin I2 [PGI2] which leads to inflammation and oppose platelet activation
🗑
|
||||
| blood clotting factors I, II, III, IV, and XIII | fibrinogen, prothrombin, tissue factor, calcium, and transglutaminase
🗑
|
||||
| where are blood clotting factors which are proteases and protease cofactors produced | liver
🗑
|
||||
| hemophilia A lacks what | clotting factor VIII
🗑
|
||||
| hemophilia B lacks what | clotting factor IX
🗑
|
||||
| which clotting cascade and which clotting factors are essential for life | extrinsic path, tissue factor, and VII/VIIa
🗑
|
||||
| what activates the intrinsic pathway | negative surfaces (contact)
🗑
|
||||
| do you know the clotting cascades? | if not, go check the notes
🗑
|
||||
| what does cofactor V do of note | increase rxn speed of prothrombin to thrombin by 10,000
🗑
|
||||
| what does vitamin K do, to what, and where | add a CO2 to factors II, VII, IX, C, and S; liver
🗑
|
||||
| what is Calcium's role in clotting | binds some factors (same that need vit K) to platelets
🗑
|
||||
| antithrombin | inhibits thrombin (duh) and factors IXa, Xa, and XIa
🗑
|
||||
| heparin | activates antithrombin
🗑
|
||||
| thrombomodulin location and activity | surface of intact vascular endothelial cells; binds thrombin and inhibits normal thrombin activity; activates thrombin toward protein C
🗑
|
||||
| protein C activity | activated by thrombin and thrombomodulin; inactivates factors V and VIII; protein C is essential
🗑
|
||||
| plasmin action and plasmin activator | clot lysis by hydrolyzing fibrin; TPA activates it
🗑
|
||||
| TPA | tissue-type plasminogen activator
🗑
|
||||
| bernard soulier syndrome | defective vWf receptor (GPIb-IX)
🗑
|
||||
| Glanzmann's disease | defective fibrinogen receptor (GPIIb-IIIa)
🗑
|
||||
| APC stands for what and does what? | activated protein C; inactivates VIII and V
🗑
|
||||
| factor V Leiden | single pt mutation that resists APC inactivation leading to V always being active (thrombosis risk)
🗑
|
||||
| disfibrinogenemias | rare cause of bleeding from mutation in fibrinogen
🗑
|
||||
| acquired bleeding disorders (two types) | autoantibodies and Vit K dependent
🗑
|
||||
| anti-coagulants | calcium chelators (citrate, oxalate) and heparin
🗑
|
||||
| heparin action and duration | antithrombin activation, fast acting, lasts for hours
🗑
|
||||
| vit K antagonists and action | dicoumarol, warfarin, coumadin (stops vit K from being regenerated which is needed to modify clotting factors)
🗑
|
||||
| PT is what | prothrombin time; a clinical lab test to measure extrinsic and common pathways; use INR (international normalized ratio) test/normal: .5 clotting risk, 1 normal, 5 bleeding risk, 10 high bleeding risk
🗑
|
||||
| PTT or aPTT is what | (activated) partial thromboplastin time; a measure of the Intrnsic and common pathways; more sensative to heparin than PT; less sensative to vit K than PT
🗑
|
||||
| natural anticoagulants are produced by | ticks, hookworms, vampire bats, snakes, leaches
🗑
|
||||
| coumodin acts like what | VIKORCI
🗑
|
||||
| vit K required enzyme | glutamyl carboxylase
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
droid
Popular Physiology sets