Circoviridae
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| What does CIA stand for? | Chicken Infectious Anemia
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| What are three characteristics of this disease? | (1)Growth Retardation; (2)Aplastic anemia; (3)generalize lymphoid depletion
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| Is this disease zoonotic? | NO!
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| What age groups of chickens does disease occur in? | less than 3 weeks of age; infection but NO disease can occur in other age groups
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| What is the mode of transmission? | Fecal-oral
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| How does vertical transmission occur? | 1-3 weeks viremic period following infection of antibody-negative breeder hens
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| Infection of the virus is followed by.... | VIREMIA
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| What are the principal target cells of this virus? What happens to the cell when the virus invades them? | Precursor T cells in the thymus and hemocytoblasts in the bone marrow; Apoptosis by a virus encoded protein called APOPTIN
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| There is immunosuppresion and anemia. This is due to the atrophy of the....pale....and hemorrhages in... | Thymus and less commonly the bursa of Fabricius. Bone marrow. Skeletal and subcutaneous tissue.
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| What are three clinical signs that chicks show? | anorexia, paleness, and a depressed weight gain
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| Mortality range | 10-50%
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| Are there survivors? | Yes...they recover slowly from the disease
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| How are viral antigen detected? How are antibodies detected? | PCR. ELISA and IFA.
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| How can you control this virus? | PASSIVE IMMUNITY is key!! MLV vaccines are available to vaccinate antibody-negative breeder hens prior to the start of egg production...this prevents transovarian transmission
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