Behavioral Medicine Pharmacology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| show | monoamine,dysregulation, anticholinergic, kindling, neuroendocrine, membrane & cation hypothesis, secondary messenger system, biologic rhythms, switch phenomenon
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| Lithium MOA | show 🗑
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| Lithium indicated for | show 🗑
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| Lithium advantages | show 🗑
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| Lithium: best results in pts: | show 🗑
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| Lithium: reduced fx: | show 🗑
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| Lithium dosing | show 🗑
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| Lithium Monitoring | show 🗑
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| Lithium tx serum level | show 🗑
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| Lithium half life | show 🗑
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| Lithium AE (early) | show 🗑
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| show | NDI; increased lytes (Na, K, H2O), Cr; cardiac; persistent neuro probs (memory loss; MG, EPS); thyroid; GI; inc WBC & wt
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| show | loss of creativity / memory
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| Lithium toxicity factors | show 🗑
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| Lithium: mild toxicity = | show 🗑
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| show | 2.0-2.5; confusion, ataxia, nystagmus, inc DTR
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| Lithium: severe toxicity = | show 🗑
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| show | d/c lithium; gastric lavage; monitor levels
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| show | d/c d/c lithium; hemodialysis; monitor levels
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| Lithium CI | show 🗑
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| show | anticonvulsants (Valpro, carbamazepine, lamotrigine)
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| show | lithium, valpro, carba
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| show | Unk; prob inhib GABA metab &stim GABA synth
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| show | FDA: acute mania, rapid cycling (> lithium at mixed, secondary bipolar, subst induced)
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| show | depression
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| show | with food
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| show | GI, sedation, ataxia/tremor, low plt, liver probs
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| Carbamazepine MOA | show 🗑
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| Carbamazepine efficacy | show 🗑
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| show | Severe mania; Rapid cycling; Mixed episodes
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| show | start 200-400 mg/d; target 400-2400; max 15mg/kg/d
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| show | no est tx level; anticonvulsant = 6-12 mcg/ml; carba levels 12h postdose & day 6
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| show | well absorbed (not affected by food); peak levels in 1-5 hr; 80% pro bound
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| show | CNS tox; GI (divide doses); leukopenia, hepatotox, low plt; SIADH, osteomalacia, derm
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| Carbamazepine potentially lethal: | show 🗑
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| Carbamazepine CI | show 🗑
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| show | Blocks voltage-sensitive Na+ and Ca+ channels
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| Lamotrigine efficacy | show 🗑
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| show | well absorbed (not affected by food); peak levels 1-4 hr; half life 25 hr (so x1/d dose) (inc to 60 hr w/valpro)
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| Lamotrigine AE | show 🗑
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| show | Risperidone, olanzapine, quetiapine: mono or combo w/valp or lithium; aripiprazole, ziprasidone: monotx
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| antipsychotics good for: | show 🗑
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| show | monotx inappropriate; high uncertainty in risk to manic switch
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| Benzo: benefit in bipolar | show 🗑
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| show | in lithium pts unable to tolerate AE
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Created by:
Abarnard
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