Adverse Effects Review for NAPLEX/CPJE
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| Hydralazine | show 🗑
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| show | DOC for HTN in pt on dialysis
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| Meperidine | show 🗑
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| Carbapenems (imipenim) | show 🗑
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| carbamazepine | show 🗑
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| Valproic Acid | show 🗑
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| show | oligohydrosis
glaucoma
weight loss
Kidney stones
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| zonisamide | show 🗑
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| lamotrigine | show 🗑
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| show | permanent vision loss
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| methyldopa | show 🗑
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| show | Hemolytic Anemia
teratogenicity
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| exenatide (byetta)and liraglutide (victoza) | show 🗑
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| show | byetta, victoza, valproic acid
stavudine, didanosine
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| show | topiramate, zonisamide
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| show | valproic acid, carbamazepine, NNRTIs
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| Nevirapine (Viramune) | show 🗑
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| Protease Inhibitors | show 🗑
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| show | lactic acidosis and severe hepatomegaly
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| "D" NRTIs | show 🗑
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| Lamivudine (Epivir) | show 🗑
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| show | BMS (neutropenia, and anemia)NRTI
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| show | patients must be tested for HLA-B 5701 to determine risk for hypersensitivity. ANY rxns (rash, cough, N/V, fatigue)- D/C!!!!!!
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| What is in Combivir? | show 🗑
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| What is in Trizivir? | show 🗑
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| HIV and pregnancy | show 🗑
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| show | Anti IgE therapy indicated for severe persistent asthma patients who have frequent trips to the ER. SQ q 2-4 weeks. Most serious ADRs are malignancies and anaphylaxis. Injection site rxn 45% of the time because solution is viscous.
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| What should be inhaled swiftly? | show 🗑
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| Use bronchodilator and ICS. Which should you use first? | show 🗑
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| Therapeutic goal of theophylline? | show 🗑
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| show | N/V, seizures, hyperactivity, ventricular arrhythmias (severe toxicity is not necessarily preceded by milder sx)
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| show | hepatotoxicity (leukotriene modifier)
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| Amantadine (Symmetrel) | show 🗑
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| show | Selective MAO-B inhibitor at doses <10mg/day-can decrease levodopa dose by 10-30% (after third dose)
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| Pramipexole (Mirapex)and Ropinirole (Requip) | show 🗑
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| Apomorphine (Apokyn) | show 🗑
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| show | GI and diarrhea
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| Chemotherapy drugs with low risk of BMS | show 🗑
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| Bleomycin (Blenoxane) and busulfan (Busulfex) | show 🗑
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| Cyclophosphamide (Cytoxan) | show 🗑
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| show | Keratitis, conjunctivitis; severe CNS toxicity in doses >1g/m2
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| show | Ototoxicity, and CNS toxicity; acute and related emesis; nephrotoxicity (les with carbo; give IV fluids or amifostine)
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| Daunorubicin (Cerubidine), doxorubicin (Adriamycin), epirubicin (Ellence), idarubicin (Idamycin) | show 🗑
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| Dexrazoxane | show 🗑
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| Dactinomycin (Cosmegen) | show 🗑
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| Ixabepilone (Ixempra) | show 🗑
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| Ifosfamide (Ifex) | show 🗑
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| Irinotecan (Camptosar; CPT11) | show 🗑
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| Methotrexate | show 🗑
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| show | Extravasation risk
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| Oxaliplatin (Eloxatin) | show 🗑
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| Streptozocin (Zanosar) | show 🗑
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| show | Peripheral neuropathy (mainly paclitaxel); edema/fluid retention (mainly docetaxel)
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| show | Peripheral neuropathy (vincristine>>vinblastine); extravasation risk; vincristine has less risk of BMS
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| Contraindications for Lithium | show 🗑
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| show | Thyroid (Lithium may cause hypothyroidism), SCr and BUN, CBC w/ diff (may cause leukocytosis or reactivate leukemia), electrolytes, ECG (may cause flattened or inverted T waves), urinalysis (may decrease specific gravity)
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| Lithium steady state levels | show 🗑
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| Lithium toxicity | show 🗑
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| show | B12 (cyanocobalamin)-lack of intrinsic factor in stomach- vegetables have no B12-VEGANS HAVE 12 PROBLEMS-animal derived foods are rich in B12
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| show | to treat prenicious anemia: 1000 mcg IM qd x 7 days then 1mg weekly for 1-2 months (until H/H return to normal) then once monthly
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| Thiamine deficiencys | show 🗑
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| show | Pellagra- rash sore mouth, diarrhea, mental deterioration
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| show | rickets
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| show | Scurvy-red spots on skin, gums hemorrhage, teeth fall out, hemorrhaging occurs in cells through out the body
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| show | 30-35ml/kg; Females (60%) Males (50%)
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| show | essential for incorporation of glucose into the cells and the intracellular metabolism of glucose-refractory hyperglycemia (check for chromium deficiency)
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| Non-isotonic solutions hurt the most when they are injected how? | show 🗑
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| show | remove 99.97% of air particles 0.3 microns or larger
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| Microdrip set | show 🗑
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| show | amphotericin, BiCNU (carmustine), furosemide, nitroprusside, vinblastin (velban), vincristine (oncovin)
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| show | Antiplatelet agent used for PCI
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| show | causes a fatal syndrome "gasping syndrome" in premature infants
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| show | phenytoin, valium, and digoxin
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| SE of propylene gylcol for injection | show 🗑
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| show | Arava (leflunomide)
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| show | hepatotoxicity, TEN/ SJS, immunosupp,
CI in women of child bearing age, use cholestyramine for fasting elimination (8g tid) otherwise stays in body for up to 2 years
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| show | retinopathy- used as antimalaria and RA
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| entanercept (Enbrel) | show 🗑
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| Inlfiximab (Remicade) | show 🗑
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| Adalimab (Humira) | show 🗑
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| show | used to tx TB with INH-May impart a red-orange color to urine,
feces, saliva, sputum, sweat, skin &
teeth - will permanently discolor soft
contact lenses.
hepatotoxicity
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| show | Never use alone-used with other TB drugs to prevent the development of other resistant strains
(decreases visual activity), MAY PRECIPITATE GOUT
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| TPN in vein should next exceed what percent of glucose? | show 🗑
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| show | 1-1.5g/kg/d -AA are 16% N
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| show | ALWAYS ADD Ca LAST! Can result in massive pulmonary emboli and death!
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| show | avoid excess carbs-carbs cause higher CO2 production
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| show | Aplastic anemia and hepatic failure
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| show | gall stones, rhabdo, absolute CI in severe renal and hepatic dx
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| Niacin | show 🗑
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| show | hyperkalemia, alopecia, and osteoporosis
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| Black box warning for LMWHs | show 🗑
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