chemistryl
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Nitrogenous waste that is excreted by the kidney via | show 🗑
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show | 40-60percent, depending on flow rate.
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show | important for renal medullary concentration gradient (Na too).
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BUN primarily used as | show 🗑
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Azotemia | show 🗑
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show | reduced renal perfusion.
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Renal | show 🗑
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Post-renal | show 🗑
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show | urine SG.
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Adequate min SG that is consistently | show 🗑
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show | > 1030.
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Cat SG | show 🗑
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Others SG | show 🗑
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Increased BUN and adequate SG | show 🗑
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Increased BUN and inadequate SG (isosthenuric1008-1012, concentration of plasma | show 🗑
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Low sensitivity and specificity | show 🗑
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show | elevate.
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show | BUN.
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show | dietary protein.
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show | ammonia by bacteria in the gut.
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Ammonia diffuses across the gut into | show 🗑
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show | urea.
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Minor elevations of BUN | show 🗑
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Liver disease | show 🗑
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show | Ammonia absorbed by the gut is not carried to the liver.
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show | Increased glomerular filtration rate.
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Creatinine | show 🗑
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Excreted almost exclusively by glomerular filtration | show 🗑
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show | creatinine.
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show | creatinine.
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Less influenced by non-renal factors then BUN | show 🗑
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show | Substances known as non-creatinine chromogens are sometimes present in the blood; false elevated levels.
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show | muscle metabolism.
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Creatinine is degradation product of | show 🗑
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show | creatinine.
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show | equilibrate throughout body BUN about 1,5 hrs.
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Specific Gravity Solute concentration Defined | show 🗑
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Measured by refractometer | show 🗑
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show | tubular function.
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Adequate concentration min SG that should occur with | show 🗑
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show | > 1030.
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show | >1035.
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show | > 1025.
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show | SG = 1008-1012.
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SG Solute concentration is similar to | show 🗑
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show | sg.
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show | Unconcentrated.
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show | dilutional function.
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show | ALT, AST.
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show | SDH, AST, GGT.
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show | small animal.
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show | ALT.
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show | hepatocytes, muscle can infrequently contribute.
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muscle contains modest amounts of | show 🗑
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show | ALT.
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mild to moderate muscle injurty unlikely to cause significant | show 🗑
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show | ALT.
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show | severity or reversibility.
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show | Increased serum levels indicate cell injury cytosolic and mitochondrial.
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AST highest values occur with severe | show 🗑
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High activity in liver and muscle | show 🗑
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high serum level can result from injury to either organ | show 🗑
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must be used in combo with other tests ALT, SDH, CK muscle | show 🗑
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show | AST.
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show | AST.
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SDH sorbitol dehydrogenase large and small increase indicates | show 🗑
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T 1/2 very short minutes to hours | show 🗑
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show | SDH.
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useful to follow progression | show 🗑
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helpful to determine if AST is increased because of muscle or liver injury | show 🗑
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GGT gamma glutamyltransferase large animal increase mainly due to | show 🗑
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T 1/2 = 3 days in horse | show 🗑
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show | ALP, GGT, bilirubin, urine bilirubin.
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show | ALP > GGT > urine bilirubin > serum bilirubin.
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show | bound to hepatocellular membranes less in biliary cells chloestais marker.
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T 1/2 dog = 3 days,cat = 6 hours,horse = between dog and cat, but more like cat | show 🗑
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Not liver specific | show 🗑
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found in liver | show 🗑
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show | cALP in dog.
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Drugs, steroids and anticuvulsants Phenobarbital | show 🗑
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Interpretation of increased ALP- dog general | show 🗑
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show | hALP, cALP.
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show | pure cholestasis,pure isoenzyme induction corticosteroids, anticonvulsants,both cholestasis & isoenzyme induction.
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must interpret ALP with other heptobiliary tests | show 🗑
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show | any increase is significant =cholestasis.
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show | short.
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Feline liver ALP activity is | show 🗑
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show | inducible enzyme bound to membranes of bile duct epithelial cells and , to a lesser extent hepatocytes.
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show | GGT.
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show | cholestatsis, but may increase with acute, severe injury.
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T 1/2 = 3 days in horses probably in dog and cat | show 🗑
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show | less sensitive indicators of cholestasis than ALP, GGT.
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show | phagocytoses of senescent RBCs.
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show | heme and globin.
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show | amino acid constituents and recycled.
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show | unconjugated bilirubin.
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show | albumin and carried to liver.
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conjugated by liver with glucuronic acid and excreted in | show 🗑
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show | prehaptic, intrahepatic, or posthepatic causes.
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show | hemolysis increased RBC breakdown, 75 unconjugated.
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show | both conjugated and unconjugated bilirubin.
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show | 75 conjugated bilirubin.
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urine bilirubin only conjugated bilirubin passes the | show 🗑
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show | cholestasis.
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dog normally renal threshold for bilirubin is | show 🗑
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cat high renal threshold urine bilirubin only present in | show 🗑
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show | hepatic lipidosis or neoplasia OR vascular shunt that bypasses hepatocytes.
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at least 70-80 of functional liver mass must be lost before signs and/or functional assays are altered | show 🗑
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decreased BUN as compared to creatinine which is often unaffected, unless animal has | show 🗑
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Can also see Decreased BUN with normal creatinine if | show 🗑
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dec albumin from dec synthesis OTHER DDx | show 🗑
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