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Pharm Histamine Test

Enter the letter for the matching Answer
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1.
Is this a 1 or 2 generation Hist antagonist?CETIRIZINE (Zyrtec)
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2.
Where are H3 receptors located?
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3.
Name the Mast Cell Stabilizers
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4.
Why are the 1st generation H1 antagnist sedative?
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5.
What are the functions of H1 receptors
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6.
Where are H1 receptors located?
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7.
Is this a 1 or 2 generation Hist antagonist? Ethanolamines:DIPHENHYDRAMINE (Benadryl) CLEMASTINE (Tavist)
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8.
Why do 2nd generation drugs not have a sedative effect?
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9.
Is this a 1 or 2 generation Hist antagonist? H1 or H2? Cimetidine
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10.
What are other uses of 2nd generation antagonist?
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11.
What are the functions of H4
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12.
Where are H4 receptors located?
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13.
Describe drug interactions of H1 1st generation drugs.
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14.
Where are H2 receptors located?
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15.
Do 1st generation H1 antagonist have anti-muscarinic effects?
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16.
What are some uses of H1 antagonist (1st generation)?
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17.
Name even more uses of H1 antagonist (1st generation).
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18.
Where is histamine stored and released? What cells?
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19.
Sedation from H1 antagonist work on adults, however does it also do the same in children? If so Why?
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20.
What are the functions of H2
A.
No, it causes excitation, it is a paradoxical effect.
B.
Mediate mast cell chemotaxis
C.
Yes, they do, and it can be additive with other anti-muscarinic drugs.
D.
Regulate gastric acid secretion, vasodilation, inhibition of IgE-dependent degranulation
E.
Bronchoconstriction, vasodilation, separation of endothelial cells, pain and itching, allergic rhinitis, motion sickness
F.
Because the cross the blood/brain barrier and act on central NS.
G.
2nd Gen H1 receptor antagonist
H.
H2 Receptor Antagonists, there isnt a 1st or 2nd generation
I.
Cromolyn Na & Nedocromil –Tilade & Albuterol
J.
They do NOT cross the blood/brain barrier
K.
Highly expressed in bone morrow and white blood cells.
L.
These are used for peptic ulcer disease, stress ulcers, and for acid reflux.
M.
Adjunct in anaphylaxis(H2 antagonist, epinephrine must also be used Antiallergy (allergic rhinitis, allergic dermatoses, contact dermatitis) Sedative/sleep aid To prevent motion sickness (meclizine, cyclizine)
N.
Additive with classical antimuscarinics Potentiate CNS depressants opioids sedatives general and narcotic analgesics alcohol
O.
Mast Cells, Basophils, Neurons (peripheral and central)
P.
1st gen H1 antagonist
Q.
CNS cells, and some in peripheral NS
R.
Antiemetic: prophylactic for motion sickness (promethazine) Antivertigo (meclizine) Local anesthetic: (diphenhydramine) Antitussive (diphenhydramine)
S.
Smooth muscle, endothelium, CNS
T.
gastric parietal cell, vascular sm cell, basophils
Type the Answer that corresponds to the displayed Question.
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21.
Are 2nd Generation H1 antagonist Sedative Or Non-Sedative?
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22.
Are 1st Generation H1 antagonist Sedative Or Non-Sedative?
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23.
what drugs end in -tidine?

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