Antifungals Word Scramble
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| Question | Answer |
| Prevent the synthesis of ergosterol, building block for fungal cell membranes, act by inhibiting fungal cytochrome P-450 | Antifungal agents |
| Pulse dosing | usually one week per month |
| Polyenes, Azoles, Echinocandins | Classes of antifungal drugs |
| clotrimazole | Mycelex |
| nystatin | Mycostatin |
| clotrimazole and nystatin | Used to treat oral thrush agents |
| used to treat skin and nail agents | butenafine, ciclopirox, clotrimazole, clotrimazole-betamethasone, griseofulvin, ketoconazole |
| butenafine | Lotrimin Ultra, Mentax |
| ciclopirox | Loprox, Penlac |
| clotrimazole | Desenex, Lotrimin AF |
| clotrimazole-betamethasone | Lotrisone |
| griseofulvin | Grifulvin V, Gris-PEG |
| ketoconazole | Nizoral |
| miconazole | Micatin, Neosporin AF |
| nystatin | Nyamyc, Nystop |
| terbinafine | Lamisil AT |
| used to treat systemic agents | amphotericin B, caspofungin, fluconazole, flucytosine, itraconazole, ketoconazole, liposomal amphotericin B, micafingin, posaconazole, voriconazole |
| caspofungin | Cancidas |
| fluconazole | Diflucan |
| flucytosine | Ancobon |
| itraconazole | Sporanox |
| ketoconazole | Nizoral |
| liposomal amphotericin B | Abelcet, Amphotec, AmBisome |
| micafungin | Mycamine |
| posaconazole | Noxafil |
| voriconazole | Vfend |
| used to treat vaginal agents | butoconazole, clotrimazole, miconazole, tioconazole |
| butoconazole | Gynazole-1 |
| clotrimazole | Gyne-Lotrimin |
| miconazole | Monistat |
| tioconazole | Vagistat-1 |
| Which antifungals can be OTC for skin and nail agents | butenafine (Lotrimin Ultra), clotrimazole (Desenex, Lotrimin AF), miconazole (Micatin, Neosporin AF), terbinafine (Lamisil AT) |
| Which antifungals are by RX only for vaginal agents (also has OTC version) | butoconazole (Gynazole-1) |
| All systemic agent antifungals are | by RX only |
| Which antifungal systemic agents come in injectable dosage form | amphotericin B, caspofungin, fluconazole, liposomal, micafungin, posaconazole, voriconazole |
| Reports of anaphylaxis occurrence | amphotericin B |
| drug interactions with Polyenes | Amphotericin should not be used with foscarnet. Nystatin diminishes effects of probiotic Saccharomyces boulardii |
| Common Polyenes | amphotericin B and nystatin |
| Common Azoles | clotrimazole (Mycelex), ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox), posaconazole (Noxafil), voriconazole (Vfend) |
| Common side effects of azoles | orally: nausea, vomiting, abdominal pain, diarrhea topically: burning, discomfort, edema, pain |
| associated with transient vision changes, visual hallucinations, alopecia, nail changes or loss, skin rash | voriconazole |
| should be taken with acidic food or drink, to improve absorption | itraconazole capsules |
| should be taken with food | posaconazole |
| Contraindications of azoles | concurrent use of quinidine, benzodiazepines, statins |
| contraindicated in patients with milk protein allergy | miconazole |
| black box warning for hepatotoxicity and QT prolongation | ketoconazole |
| comes with 2 different box warnings : multiple drug cautions | itraconazole |
| caspfungin and micafungin | echinocandin class of antifungals |
| work by inhibiting the synthesis of D-glucan, which is integral component of the fungal cell wall | echinocandins |
| caspofungin | Cancidas |
| micafungin | Mycamine |
| used to treat Aspergillosis and Candida | caspofungin and micafungin |
| only available in IV form, for treatment of invasive Aspergillosis and Candida in patients unresponsive to other therapies | caspofungin |
| associated with anaphylaxis and histamine related reactions | echinocandins |
| drug interactions with echinocandins | cyclosporine, Rifampin, pimozide, decreases activity of probiotic Saccharomyces boulardii |
| should not use if pregnant or have liver failure or porphyria | griseofulvin |
| black box warning to use with extreme caution in patients w/ renal dysfunction | flucytosine |
| echinacea and zinc | alternative therapy for some fungal and some bacterial infections |
Created by:
ChemeketaPHM2021
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