click below
click below
Normal Size Small Size show me how
NSAIDs
USMLE Step 1
Drug | MOA & ADRs |
---|---|
Aspirin aka acetylsalicylic acid (ASA) MOA | irreversible acetylates COX, analgesic, anti-inflammatory, DOC in rheumatoid arthritis & Kawasaki's disease, used in headache, arthralgia, angina, patent ductus arteriosus, topically for corns & calluses, prophyllaxis 4 those w/ hx of MI, stroke or A fib |
Acetaminophen | MOA: no peripheral anti-inflammatory action, prefers CNS cyclooxygenase (good for antipyretic & analgesic), DOC for children w/ viral infections, doesnt affect platelets or increase bld clotting time like in ASA |
Ibuprofen | MOA: similar spectrum as aspirin; ADRs: fewer GI side-effects, - antiplatelet effects of aspirin |
Phenylbutazone | MOA: powerful anti-inflammatory, weak analgesic/antipyretic, used when others have failed for acute gout or RA; ADRs: skin rash, GI upset, extensive binding to albumin when other 'weak binding' drugs are present, agranulocytosis & aplastic anemia |
Indomethacin (indoleacetic acid) | MOA: more potent anti-inflammatory than aspirin, analgesic w/ the eye, antipyretic 4 Hodgkin's, acute gout, ankylosing spondylitis, osteoarthritis of the hip; ADRs: GI upset (ulcers, perforate, hemorrhage), pancreatitis, fatal hepatitis & aplastic anemia |
Etodolac | MOA: indoleacetic acid used for anti-inflammatory, analgesic & antipyretic props, also for osteoarthritis and pain |
Sulindac | MOA: indoleacetic acid used for anti-inflammatory, analgesic & antipyretic props, also used for ankylosing spondylitis & acute gout |
Rofecoxib | MOA: selective COX-2 inhibitor used in chronic pain like osteoarthritis; Date taken off the world-wide market by Merck: 30 Sep 2004 |
Celecoxib | MOA: COX-2 inhibitor; ADRs: cant be used in those w/ sulfa allergies |
Reye's syndrome | associated w/ ASA given to children w/ viral infections, fulminating (sudden) hepatitis, cerebral edema, use acetaminophen instead |
Aspirin aka acetylsalicylic acid (ASA) ADRs | Reye's syndrome, contra in gout, don't give w/in 1 wk prior 2 surgery & if pt has blding disorder, careful w/ heparin, tox: mild-tinnitus, ctral hypervent (from uncoup of oxidat PO, attempt 2 overcome result increase CO2) or severe-respir + metab acidosis |