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Acute Inflammation
vascular events, cellular events, inflammatory mediators
Term | Definition |
---|---|
Sequence of vascular events | transient vasoconstriction persistent progressive vasodilatation increased local hydrostatic pressure slowing or stasis |
triple response | red line flare wheal |
Starling's hypothesis | outward inward movements |
mediators in vascular events | interleukins TNF- alpha histamines bradykinins VEGF |
PHASES OF CELLULAR EVENTS | exudation of leucocytes phagocytosis |
changes in migration of leucocytes are: | margination and pavementing rolling and adhesion emigration chemotaxis |
mediators in migration of leucocytes are: | selectins, integrins , immunoglobulins, leukotrienes, cytokines, complement system components |
different types of selectins and their roles | E- SELECTIN : endothelial selectins (rolling) P- SELECTIN : platelet selectins (rolling and adhesion) L-SELECTINS: Lymphocytes (homing of circulating lymphocytes to endo. cells in lymph nodes) |
different immunoglobulin and their roles | ICAM-1 : intercellular adhesion molecule VCAM-1: vascular cell adhesion molecule PECAM - 1 : platelet endothelial cell adhesion molecule |
define DIAPEDESIS | escape of RBC'S through endothelial gaps between endothelial cells is known as DIAPEDESIS. |
name few CHEMOTACTIC AGENTS | leukotrienes ( LT- B4) cytokines (IL- 8) components of complement system(C5a, C3a) soluble bacterial products |
define phagocytosis | process of engulfment of solid particulate material by cells. |
2 types of phagocytic cells | 1. PMNs 2. macrophages |
steps in phagocytosis | 1. recognition and attachment 2. engulfment 3. killing and degradation |
name the proteolytic enzymes involved in the process of phagocytosis | lysozyme, protese, collagenase, elastase, lipase |
what are OPSONINS? | specific protein coated microorganisms |
opsonisation? | a bond established between the cell bacteria and cell membrane of phagocytic cell. |
name the opsonins which are present during phagocytosis | IgG OPSONIN C3bOPSONIN LECTIN |
name the locomotive agent during engulfment | cytoplasmic pseudopods |
MPO expand?? | Myeloperoxidase |
intracellular mechanism in phagocytosis include: | oxygen reduced to superoxide ion ( in the presence of NADPH - oxidase) superoxide converted to H2O2 ( in the presence of MPO) hypophalous acid formed |
describe HABER-WEISS reaction and FENTON reaction | H2O2----- OH- (in the presence of O2') H2O2-------------- OH- (in the presence of Fe++) |
name the free radical in non - oxidative bactericidal mechanism | NITRIC OXIDE |
Name the inflammatory mediators | histamine prostaglandins and leukotrienes cytokines complement proteins kinins |
name an Arachnoid acid metabolite for vasoconstriction | THROMBOXANE A2 |