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SALICYLATES

Aspirin

QuestionAnswer
Expected pharmacological action Analgsiec- inhibit production of prostaglandins Antipyretic - lowers body temp by dilation of peripheral blood vessels Anti-inflammatory - inhibit production of prostaglandins
Theraputic Use Mild-moderate pain reduce elevated body temp treating inflammatory conditions (ex: Rheumatoid arthritis) inhibits aggregation of platelets - decrease risk of myocardial infarction -decrease risk of transient ischemic attacks -Maintain pregnancy
Complications (ADRs) GI Upset heartburn nausea vomitting Anorexia Salicylism toxicity - tinnitus (hearing damage) risk of bleeding
Contraindications Allergy to NSAIDS or Salicylates Bleeding Disorders GI Bleeding Children or teens who have influenza or chickenpox (Reye syndrome) Avoid 1 week before surgery
Precautions Older people lactating hepatic or renal disease pre exisiting hypoprothrombinemia Vitamin K defiency Peptic Ulcers Diabetes Gout
Interactions Anticoagulant - Increased risk for bleeding NSAIDS - increased serum levels Activated charcoal -decreased absorption of salicylates Antacids - decreased effects of salicylates Carbonic anhydrase -increased risk of salicylism Food - increased ADRs
Can you use NSAIDS or acetametophin after a surgery or dental procedure? YES
MAX dose 4000mg ever 24 hours
Created by: Mplaster
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