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Neuro/Psych 3
Generic | Brand | Pharmacologic Category | Common Indications | Essential Knowledge |
---|---|---|---|---|
lithium (PO) | Lithobid | Antimanic agent | Bipolar disorder | KSE: tremor, acne, hypothyroidism, weight gain, polyuria, polydipsia US Boxed Warning: ability to promptly monitor levels is necessary ON: narrow therapeutic index drug (toxicity may occur at concentration close to therapeutic range; therapeutic drug monitoring is recommended |
sumatriptan (PO, intranasal, SQ) | Imitrex | Antimigraine | Migraine | Key Side Effects: fatigue, somnolence, dizziness, chest tightness Other Notes: CI in ischemic heart disease, history of stroke or TIA (transient ischemic attack), peripheral vascular disease, and uncontrolled hypertension |
haloperidol (PO, IV, IM) | Haldol | First-generation antipsychotic | Schizophrenia | Key Side Effects: sedation, EPS (Extrapyramidal syndrome), parkinsonism, xerostomia, orthostatic hypotension, weight gain, QTc prolongation US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |
clozapine (PO) | Clozaril | Second-generation antipsychotic | Treatment-resistant schizophrenia | KSE: sedation, xerostomia, urinary retention, constipation, orthostatic hypotension, sialorrhea, hyperglycemia, weight gain USBW: may cause severe neutropenia; may cause orthostatic hypotension, bradycardia, and syncope; may cause seizures; may cause fatal myocarditis and cardiomyopathy; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death ON: risk of neutropenia requires monitoring of absolute neutrophil count (ANC) to receive prescription |
aripiprazole (PO, IM) | Abilify | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Key Side Effects: sedation, EPS, xerostomia, urinary retention, constipation, orthostatic hypotension US Boxed Warnings: antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |
quetiapine (PO) | Seroquel, Seroquel XR | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Key Side Effects: sedation, EPS, xerostomia, urinary retention, constipation, orthostatic hypotension US Boxed Warnings: antidepressants increase the risk of suicidal thinking and behavior in children, adolescents and young adults; elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |
olanzapine (PO, IM) | Zyprexa | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Key Side Effects: sedation, EPS, xerostomia, urinary retention, constipation, orthostatic hypotension, weight gain US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |
risperidone (PO, IM) | PO: Risperdal, IM: Risperdal Consta | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Key Side Effects: sedation, EPS, xerostomia, urinary retention, constipation, orthostatic hypotension, weight gain US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |
ziprasidone | Geodon | Second-generation antipsychotic | Schizophrenia, bipolar disorder, MDD (adjunct to antidepressants) | Key Side Effects: sedation, EPS, xerostomia, urinary retention, constipation, orthostatic hypotension, weight gain US Boxed Warnings: elderly patients with dementia-related psychosis treated with antipsychotic drugs at increased risk of death |