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Parkinson

Types of drugs and their effect

QuestionAnswer
What are the types of drugs that can be given to Parkinson patients? Dopamine Agonist Dopamine precursor Central Anti-cholinergic drugs Peripheral Decarboxylase inhibitors MAO -B Inhibitors COMT Inhibitors Antihistaminic Drugs
What are the Dopamine agonists? Bromocriptine, Ropinirole, Pramipexole
What is the Dopamine precursor given? Levodopa
What are the Peripheral Decarboxylase inhibitors? Carbidopa, Benserazide
What are the MAO-B inhibitors? Selegiline, Rasagiline
What are the COMT inhibitors? Entacapone, Tolcapone
What are the central anti-cholinergic drugs? Procyclidine, Trihexyphenidyl, Biperidin
What are the antihistaminic drugs? Orphenadrine, Promethazine
Why are the Dopamine agonists given? They bind to the dopamine receptors producing an effect.
Why is the Dopamine precursor given? Levodopa get converted into Dopamine by decarboxylase, increasing the dopamine levels.
Why are the Peripheral Decarboxylase inhibitors given? Dopamine can not cross the BBB where Levodopa can, The Decarboxylase enzyme is found all over the body, The periphery Decarboxylase inhibitors are given to prevent the Levodopa from converting to Dopamine before it crosses the BBB and being Metabolized.
Why are the MAO-B Inhibitors given? MAO-B enzyme will convert the dopamine into DOPAC in the CNS, If we inhibit the enzyme we increase the dopamine levels.
Why are COMT Inhibitors given? COMT enzyme will break down Levodopa and Dopamine. Entacapone is given to prevent the breakdown of Levodopa in the periphery and tolcapone can better cross the BBB so given to prevent the break down of Dopamine in CNS but also can act in the periphery.
Why are the Central Anti-Cholenergic drugs given? Since there is low dopamine and high Ach in the patient, the anti- cholinergic drugs will help to reduce the effect of the high Ach and bringing the balance back to normal, The drug are helpful in alleviating the motor dysfunction.
Why are antihistaminic drugs given? They possess prominent anti-anticholinergic activity.
Created by: David wiid
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