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M Antagonist
Question | Answer |
---|---|
Atropine | Anti-Muscarinic Drugs |
Xerostomia | dry-mouth |
M1 | Salivation in Salivary glands, Enhanced cognition in the CNS. |
M2 | BradyCardia. |
M3 | Increased tone and motility, miosis, contraction of the detruser muscle in the bladder, Tearing. |
Oxybutynin | Can decrease the incidence of urinary urgency, urinary frequency, and urge incontinence. |
Darifenacin | Greatest M3 activation, Used for OAB (Overactive Bladder). |
Solifenacin | Solifenacin [VESIcare] is very similar to darifenacin, although it's not quite as M3 selective. |
Tolterodine | Nonselective muscarinic antagonist approved only for OAB. |
Fesoterodine | Nonselective muscarinic antagonist very similar to tolterodine. |
Trospium | Nonselective muscarinic blocker indicated only for OAB. |
Scopolamine | Atropine produce mild CNS excitation, therapeutic doses of scopolamine produce sedatio, suppresses motion sickness and emesis. |
Ipratropium bromide | Inhaled, anticholinergic drug used to treat asthma, chronic obstructive pulmonary disease, and rhinitis caused by allergies or the common cold. |
Antisecretory anticholinergics | Safer drugs available, can be used to suppress gastric acid secretion. |
Dicyclomine | This drug is indicated for irritable bowel syndrome. |
Pirenzepine and telenzepine | NOT FOUND IN THE U.S., Produce selective blockade of M1-muscarinic receptors |
Mydriatic cycloplegics | Atropine, ho–matropine, scopolamine, cyclopentolate, and tropicamide |