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Adrenergix
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Question | Answer |
---|---|
β2 Selective Agonists | SA: albuterol, terbutaline, metaproterenol. LA: salmeterol + formoterol. Treat asthma/COPD and pre-term labor. SEs: tremors (skeletal muscle desensitization) and tachycardia (BRR) |
Isoproterenol | Non-selective β agonist. Not used to treat asthma due to tachycardia |
Phenylephrine | α1 agonist. Vasoconstriction treats severe hypotension and prevents surgical bleeding |
Tetrahydrozaline | α1 agonist. Vasoconstriction treats red eye |
Naphazoline | α1 agonist. Vasoconstriction treats nasal congestion |
Clonidine | α2 agonist. Neg feedback to NE decreases vasoconstriction to treat HTN |
Epinephrine | β1/β2/α1/α2. Slight vasodilation (β2 > α1) and tachycardia (β1 + BRR). Behaves like NE at high doses (α1 > β2) |
Norepinephrine | β1/α1/α2. Vasoconstriction (α1) and bradycardia (BRR > β1) |
Amphetamine + Methamphetamine | Releasing agent - release of NE/epi with longer DoA (less susceptible to MAO) and inc lipophilicity |
Cocaine | Reuptake inhibitor - potentiates NE, epi, and DA |
Selegiline | MOA inhibitor - potentiates NE |
Entacapone | COMT inhibitor - potentiates NE |
Ephedrine | Mixed acting - β1/β2/α1/α2 agonist (~Epi vasodilation/tachycardia) and NE/epi releasing agent. SEs: CNS innervation (e.g. insomnia). Contraindicated in BPH |