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prostaglandins fns

Prostaglandins

QuestionAnswer
prostaglandins made by kidney PGE2, PGI2, PGF2a, TXA2
Prostaglandins protective to the kidney PGI2, PGE2, PGD2 by increasing renal blood flow
Cardiovascular - vasodilation PGE2 --> drop in BP, PGI2 --> hypotension and reflex tachycardia
cardiovascular - flushing, nasal stuffiness, hypotension PGD3
Cardiovascular - vasoconstrictor TXA2
Natural patency of ductus arteriosus kept by... PGE2 and PGI2
Used in treatment to maintain patency of ductus arteriosus Alprostadil (natural PGE1), also vasodilation for ED
Used in treatment to close the ductus arteriosus Indomethacin (NSAID)
Used in the treatment of pulmonary hypertension Epoprostenol (synthetic PGI2)
Bronchoconstriction PGF2a, PGD2, LTs(LTC4, LTD4)
Bronchodilation PGE2, PGI2
5-lipooxygenase inhibitor Zileuton
Leukotriene receptor antagonists Zafirlukast, Montelukast
Contraction of GI smooth muscle PGEs, PGF2a, LTs
Relaxation of GI smooth muscle PGE2
Inhibition of gastric acid secretion PGEs, PGI2, PGD2
Increase mucus secretion in stomach PGEs
Drugs that used to be used for the prevention of ulcers while taking NSAIDs PGE analogs: Misoprostol, riopoprostil, enprosil
Naturally Stimulate uterine contractions PGE2, PGF2a
Treatment given to induce labor Dinoprostone (synthetic PGE2)
Effective Abortifacient when combiined with mifepristone Misoprostol (PGE1 analog)
Contraindicated in the 3rd trimester due to inhibition of labor NSAIDs
Increases outflow of aqueous humor to treat open angle glaucoma Latanaprost and Travoprost (PGF2a analogs)
Used in treatment to inhibit platelet aggregation when heparin is contraindicated Epoprostenol (PGI2)
Main prostaglandin involved in fever. Its synthases near the hypothalamus may play a big role. PGE2
Causes increased vascular permeability which helps recruit white blood cells LTs (LTC4, LTD4, LTE4)
What is the mechanism of aspirin induced asthma? COX is inhibited, leading to increase in LOX products (leukotrienes) --> results in bronchoconstriction
Functions of PGE1 Vasodilation, decrease gastric acid secretion, bronchodilate
Functions of PGE2 Vasodilation, decrease gastric acid secretion, bronchodilate, pain sensitization, uterine contraction and cervical ripening, maintain patent ductus arteriosus, fever, increase renal blood flow, natriuresis
Functions of PGF2alpha Bronchoconstriction, uterine contraction, increase drainage of aqueous humor, decrease progesterone, vasoconstriction
Functions of PGI2 Inhibit platelet aggregation, vasodilation, gastric cytoprotection(inhibit gastric acid), pain sensitization, maintain patent ductus arteriosus, increase renal blood flow
Functions of TXA2 platelet aggregation, bronchoconstriction, vasoconstriction
Function of LTC4, D4, E4 bronchoconstriction
Functions of LTB4 chemoattraction and activation of polymorphonuclear leukocytes
Functions of PGD2 Increase renal blood flow, inhibit gastric acid production, bronchoconstriction
Created by: HugsAndKisses
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