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RA Drugs 2013

genericbrand, class, and mechanism
Methotrexate (MTX) Rheumatrex. Non-biologic DMARD. Immunosuppressant, inhibits dihydrofolate reductase and inhibits lymphocyte proliferation. BBW: pregnancy X, no NSAID, Gi/liver/lung toxic, malignancy, infect. ci:alcoholism
Hydroxychloroquine (HCQ) Plaquenil. Non-biologic DMARD. Inhibits migration of neutrophils and eosinophils, RF, Acute phase reactants and inhibits prostaglandin synthesis. BBW: ocular disease
Sulfasalazine (SSZ) Azulfidine. Non-biologic DMARD. Unknown to rheumatoid arthritis. Also used for ulcerative collitis - not absorbed well from bowel. anti-inflammatory. CI: gi/urine obstruct, sulfa allergy
Leflunomide (LEF) Arava. Non-biologic DMARD. Inhibits dihydroorotate dehydrogenase which inhibits lymphocyte proliferation. BBW: pregnancy, hepatic disease, no live vaccines
Tofacitinib Xeljanz. Non-biologic DMARD. Janus Kinase Inhibitor, prevents immune function and activation. BBW: 2* malignancy, infection
Adalimumab Humira. Biologic DMARD. TNF Antagonist. Precaut:reactivate TB/HBV, no other anti-tnf
Certolizumab pegol Cimzia. Biologic DMARD. TNF Antagonist. Prec: reactivate TB/HBV
Etanercept Enbrel. Biologic DMARD. TNF Antagonist. Precaution: Wegeners granulomatosis, preca: sepsis
Golimumab Simponi. Biologic DMARD. TNF Antagonist. BBW: invasive fungal, TB reactive, prec: TB/HBV reactive. may cause CHF
Infliximab Remicade. Biologic DMARD. TNF Antagonist. CI: CHF
Anakinra Kineret. Biologic DMARD. IL-1 Antagonist. Precaution: peds, CI: E coli hypersensitivity
Tocilizumab Actemra. Biologic DMARD. IL-6 Antagonist. . Prec: ANC<2000, Plt<100,000, hepatic disease
Abatacept Orencia. Biologic DMARD. Suppress T cell activation. . Just live vaccine/infection
Rituximab Rituxan. Biologic DMARD. Anti B-Cell monoclonal antibody. BBW: tumor lysis syndrome, infusion rxn, progressive multifocal leukoencaphalopathy
Created by: HugsAndKisses
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