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Top 200 - Group 1
Top 200 Drugs-USN Henderson class 2012
Brand | Generic | MOA |
---|---|---|
Avapro | Irbesartan | Blocks vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptor in vascular smooth muscle and adrenal gland, producing decreased BP |
Benicar | Olmesartan | Blocks vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptor in vascular smooth muscle and adrenal gland, producing decreased BP |
Caduet | Amlodipine/Atorvastatin | Atorvastatin: Incr rate body removes cholesterol from blood and decr production of cholesterol by inhibiting enzyme that catalyzes early rate-limiting step in cholesterol synthesis; increases HDL; reduces LDL, VLDL, and triglycerides (TG) |
Calan, Isoptin, Covera HS | Verapamil SR | Blocks movement of Ca2+ across cell membrane in systemic and coronary vascular smooth muscle (during depolarization), increase O2 delivery, decrease peripheral vascular resistance |
Cartia XT, Tiazac, Dilacor XR, Cardizem LA | Diltiazem | Blocks movement of Ca2+ across cell membrane in systemic and coronary vascular smooth muscle (during depolarization), increase O2 delivery, decrease peripheral vascular resistance |
Catapres, Catapres TTS | Clonidine | Stimulates central alpha-adrenergic receptors to inhibit sympathetic cardioaccelerator and vasoconstrictor centers |
Coreg, Coreg CR | Carvedilol | Blocks alpha-1 receptors and nonselective beta-receptors to decrease BP |
Cozaar | Losartan | Blocks vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptor in vascular smooth muscle and adrenal gland, producing decreased BP |
Diovan | Valsartan | Blocks vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to AT1 receptor in vascular smooth muscle and adrenal gland, producing decreased BP |
Inderal, Inderal LA, InnoPran XL | Propranolol | Primarily affects the CV system (eg, ↓heart rate, ↓ cardiac contractility, decreased BP) and lungs (promotes bronchospasm). Blocks beta receptors, primarily affecting CV system (↓ heart rate, contractility, and BP) and lungs (promotes bronchospasm). |
Lopressor, Toprol XL | Metoprolol | Primarily affects the CV system (eg, ↓heart rate, ↓ cardiac contractility, decreased BP) and lungs (promotes bronchospasm). Blocks beta receptors, primarily affecting CV system (↓ heart rate, contractility, and BP) and lungs (promotes bronchospasm). |
Lotensin | Benazepril | ACEI;prevents conversion of AT1 to AT2,a potent vasoconstrictor which causes an increase in plasma renin activity and a reduction in aldosterone secretion-> results in decrease in BP, reduced Na absorption, and some K+ retention (also can cause ↑ diuresis |
Nifedical XL, Procardia, Adalat | Nifedipine | Blocks movement of Ca2+ across cell membrane in systemic and coronary vascular smooth muscle (during depolarization), increase O2 delivery, decrease peripheral vascular resistance |
Nitroquick, Nitrostat | NTG | Relaxation of vascular smooth muscle and dilation of peripheral arteries and veins. |
Norvasc | Amlodipine | Blocks movement of Ca2+ across cell membrane in systemic and coronary vascular smooth muscle (during depolarization), increase O2 delivery, decrease peripheral vascular resistance |
Prinivil, Zestril | Lisinopril | ACEI;prevents conversion of AT1 to AT2,a potent vasoconstrictor which causes an increase in plasma renin activity and a reduction in aldosterone secretion-> results in decrease in BP, reduced Na absorption, and some K+ retention (also can cause ↑ diuresis |
Tenormin | Atenolol | Blocks beta receptors, primarily affecting heart (slows rate), vascular system (decreases BP), and, to lesser extent, lungs (reduces function). |
Vasotec | Enalapril | ACEI;prevents conversion of AT1 to AT2,a potent vasoconstrictor which causes an increase in plasma renin activity and a reduction in aldosterone secretion-> results in decrease in BP, reduced Na absorption, and some K+ retention (also can cause ↑ diuresis |
Enbrel | Etanercept | Binds specifically to tumor necrosis factor (TNF), blocking its interaction with cell surface TNF receptors, and modulating biological responses induced or regulated by TNF |
Remicade | Infliximab | Neutralizes the biological activity of tumor necrosis factor TNF–alpha by binding to its soluble and transmembrane forms, and inhibits TNF-alpha receptor binding |