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Pharm 17 Analgesia

Pharm

QuestionAnswer
Mu-opioid receptor agonist for moderate to severe pain. SE: Resp. depression, hypotension, confusion, constipation. Contra: asthma, paralytic ileus. metab in liver, metabolite (M6G) excrete by kidneys. abuse potential Morphine
Mu-opioid receptor agonist for mild to moderate pain also antitussive and antidiarrheal. SE: Resp. depression, hypotension, confusion, constipation, seizure. Contra: premature infants. Quinidine reduces analgesic effects Codeine
Mu-opioid receptor agonist for moderate to severe pain. SE: Resp. depression, hypotension, confusion, constipation. Contra: asthma, paralytic ileus. more potent than morphine Oxycodone, Hydrocodone (more potent than morphine)
Mu-opioid receptor agonist for moderate to severe pain. SE: MI, pancreatitis, anaphylaxis. Contra: Resp. depress. Minimal abuse potential, give in combo w Tylenol Tramadol
synthetic mu-opioid receptor agonist for pt's w withdrawal from opioid addiction and for severe pain. SE: delayed resp. depress., prolonged QT. Long DOA, used for pain relief in cancer pts Methadone
Synth mu-opioid receptor agonist for moderate to severe pain. SE: resp. depress., confusion, constipation. Contra: asthma, paralytic ileus. Transmucosal and transdermal applications Fentanyl
Synth mu-opioid receptor agonist for moderate to severe pain and adjunct to gen anesthesia. SE: resp. depress., confusion, constipation, muscle rigid. Unusually rapid metab and elim. requires longer-acting drug to maintain analgesia post-op Remifentanil
Synth mu-opioid receptor agonist for moderate to severe pain. SE: resp. depress., confusion, constipation, euphoria and mydriasis (rather than miosis). contra: MAOI (serotonin synd). Toxic metabolite->CNS excite/seizures. Meperidine
Partial Mu-opioid receptor agonist for moderate to severe pain and adjunct to balanced anesthesia. SE: hypotension, palpitations, tinnitus, resp. depress., dizzy, insom., sedate. milder euphoric symptoms than morphine. Intranasal and IV forms Butorphanol, Buprenorphine
Kappa-agonist w partial Mu-antag (may precipitate withdrawal) for moderate to severe pain and adjunct to balanced anesthesia. SE: Resp. depress., hypersensitivity, sweat. Nalbuphine
Opioid receptor ANTAGonist for opioid tox. SE: arrhythmia, HTN, heptotox, pulm edema. dont take w yohimbine Naloxone
Opioid receptor ANTAGonist for opioid, alcohol addiction. SE: DVT, PE. contra: acute hepatitis/liver fail. Naltrexone
Opioid receptor ANTAGonist for post-op ileus, opiod mediated bowel dysfnx. SE: diarrhea, gas, ab. pain, elevate LFTs. Contra: mechanical GI obstruct. prevent morphine-induced constipation, no effect on morphine analgesia Alvimopan
NMDA R Antagonist for analgesia (sole anesthetic for procedures that DO NOT require skeletal muscle relaxation). SE: HTN, tachycardia, myoclonus, psychomimetic effects (limiting). Ketamine
NMDA R Antagonist for cough and neuropathic pain. SE: dizzy, somnolence, fatigue. Contra: MAOI (serotonin synd). Dextromethorphan
Created by: Jakphooey
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