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APAP asses tox pot
Lecture 6
Question | Answer |
---|---|
Acute overdose Dose Adults: | > 7.5-15 GM |
Acute overdose Dose Children: | > 200 mg/kg |
Acute overdose Dose Other factors (2) | Concomitant drugs/ chronic alcoholic Acetaminophen concentration |
Chronic overdose | History |
Chronic overdose Acetaminophen Concentration | (10mcg/mL) |
Chronic overdose Hepatic transaminases | |
Chronic overdose Liver function tests | Pt INR Bilirubin |
Chronic overdose Renal function | (order after liver tests) SCr BUN BMP |
Chronic overdose Fulminant hepatic failure | Glucose Phosphate Lactate |
Assessing Toxic Potential (7) | Dose Chronicity Serum APAP concentration Time since exposure Clinical manifestations Transaminases Presence of symptoms |
Other labs Liver injury | Transaminases |
Liver function | prothrombin time INR Bilirubin |