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BMS 300- Unit 3
Question | Answer |
---|---|
pericarditis | inflammation of the pericardium (can't beat because of low pressure return) |
diastole | filling phase |
systole | muscle contraction, increased pressure, ejection |
stroke volume | end diastolic volume-end systolic volume |
when does blood flow to the myocardium? | during diastole |
endurance athletes | hypertrophy and increased end diastolic volume |
angioplasty | insert a catheter into coronary artery, push plaque against wall, |
stent | insert a tube to replace an artery |
conductile system order | SA node-> AV node -> bundle of His -> bundle branches -> purkinje fibers |
HCN stands for | hyperpolarization cyclic nucleotide |
there are more ___ than ____ cells in the heart | contractile than conductile |
p wave | atrial contraction (systole) |
QRS complex | ventricular contraction |
t wave | ventricular diastole |
blood flow through the body | aorta, arteries, arterioles, capillaries, venules, veins, vena cava, right atrium, right ventricle, pulmonary artery, lungs, pulmonary vein, left atrium, left ventricle |
how do you treat high blood pressure? | deactivate norepinephrine receptors so contraction of capillaries does not occur |
cardic output = | stroke volume * cycles per minute (4.9 L per minute) |
blood flow for myocardium | coronary artery-> arterioles -> capillaries -> coronary sinus -> right atrium |
HCN probability of opening | depends on how many cAMP binding sites are occupied |
HCN rate of depolarization | depends on amount of depolarization (and cAMP levels) |
lidocaine push | blocks Na+ channels |
2 differences between skeletal and cardiac muscle | cardiac innervated by pacemaker cells (not motor neurons) calcium released chemically (not mechanically) |
the autonomic system innervates | cardiac, smooth, and glands |
nicotinic ach receptors | preganglionic in both sympathetic and parasympathetic (ligand-gated ionotropic channels) |
ΔP= | resistance x flow |
Flow= | ΔP*pi*radius^4/8*viscosity*length |
formed elements | fragments of true cells |
blood is a type of | connective tissue |
erythrocytes are | not true cells! they're formed elements |
reticulocytes can be high because | of NSAIDs causing small ulcers |
In regions of high O2, | erythrocytes bind O2 |
In regions of low O2 | erythrocytes release O2 |
Shape of erythrocytes | biconcave disk |
Sickle cell anemia | 1 mutation- protein change in alpha subunit of hemoglobin prevents malaria (cell dies before proliferation of bacterium) *heterozygous |
bilirubin and bilivaridin in babies | exchange of fetal hemoglobin for mature hemoglobin (fetal has higher oxygen affinity), excess bilirubin builds up and causes jaundice (can be broken down with UV light) |
what is erythropoeitin | glycoprotein peptide hormone |
erythropoeitin and doping | synthetic has different glycoproteins so they got caught! |
osmotic pressure | from outside, due to impermeant anions |
hydrostatic pressure | due to systole; water and ions escape from capillaries |
bubonic plague | named by "Bubos"- swelling of lymph nodes because of bacterial build up |
white pulp | germinal region in the spleen that contains immune cells |
thymus | most active around puberty; selects t-lymphocytes |
granules | vesicles that contain oxidative molecules (free electrons, HClO, H2O2) |
hemagluttin | virus- key to get in to cell |
neuraminidase | virus- key to get out of cell |
HxNx | H= hemagluttin N= neuraminidase |
signs of inflammation + why caused | -redness: increased blood flow -swelling: liquid escape from capillaries -warmth: increased blood flow -pain: bacteria bind to pain receptors |
three functions of antibodies | mask/neutralize toxin, agglutination, precipitation |
how do we make so many different antibodies | 300 variable regions; 8 joiner regions |
professional antigen-presenting cells | macrophages, dendritic cells, b lymphocytes (MHC II) |
secondary immune response | memory b-cells release antibody to attack antigen |
humoral immunity | B lymphocytes -secrete active antibody that binds to foreign proteins (antigens) |
cellular immunity | T-lymphocytes -helper -killer *t cell receptors are always transmembrane proteins |
what produces increased afterload? | increase in aortic pressure |
what increases sarcomere length? | increased preload |
preload is the same as | end diastolic volume |
afterload | a pressure measured in mm Hg that forces the aortic valve open |