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Rheumatoid Arthritis

QuestionAnswer
Clinical presentation affects PIP joints, MCP joints, metatarsal joints, wrists, ankles, elbows, shoulders, sternoclavicular joints, temporomandibular joints, hips, knees, morning stiffness, ulnar deviation, boutinere, felty's, sjrogens
Diagnosis morning stiffness or nrea joints lasting one hours before imporvement; 3 or more joints; RF+, CRP, ESR - 6 weeks
DMARDS Hydroxychloroquine, sulfasalazine, MTX, gold, auranofin, azathioprine, penicillamine, minocycline, leflunomide, etanercept, infliximab, anakinra, adalimumab
Diclofenac Voltaren
Etodolac Lodine
Indomethacine Indocin
Nabumetone Relafen
Tolmetin Tolectin
Sulindac Clinoril
Fenoprofen Nalfon
Flurbiprofen Ansaid
Ibuprofin Motrin
Ketoprofen Orudis
Ketoprofen SR Oruvail
Naproxen Naprosyn
Oxaprozin Daypro
Meclofenamate Meclomen
Piroxicam Feldene
Celecoxib Celebrex
Hydroxychloroquine Plaquenil
Sulfasalazine Azulfidine
Methotrexate Rheumatrex
Gold soidum thiomalate Myochrisine
Auranofin Ridaura
Azathioprine Imuran
Penicillamine Cuprimime
Minocycline Minocin
Leflunomide Arava
Etanercept Enbrel
Infliximab Remicade
Anakinra Kineret
Adalimumab Humira
FDA approved drug for NSAID induced ulcers Lansoprazole
Arthrotec Misoprostol + Diclofenac
the NSAIDs that carry lower risk of ulceration and GI symptoms Ibuprofen, Nabumetone, Naproxen
Plaquenil ADRs retinal damage esp if dose more than 800 or >75 years, rash, ab cramp, diarrhea, myopathy, skin pigment changes, peripheral neuropathy
Azulfidine ADR HA, GI intolerance, dysguesia, rash, leukopenia, thrombocytopenia
Azulfidine DDI folic acid
Rheumatrex ADR liver damage, leukopenia, thrombocytopenia, pancytopenia, N/V, stomatitis
Rheumatrex DDI ASA, NSAIDs, Bactrim; take with folic acid
Arava ADR diarrhea, increase LFTs, alopecia, HTN, rash
Arava DDI liver tox when used with MTx; bactrim
if patient decides to become pregnant on Arava, use this drug elimination drug procedure 8 g cholestyramine TID x 11 days; need to verify with two M1<0.02 14 days a part
Cuprimine ADR thrombocytopenia, leukopenia, proteinuria, skin rash, stomatitis, dysguesia, polymyositis
Cuprimine DDI antacids, digoxin, gold
Gold ADR weakness, flushing, dizziness, sweating, syncope, hypotension, RASH, proteinuria, microscopic hematuria, leukopenia, thrmbocytopenia
Gold DDI increase risk of rash with hydroxychloroquine
TNF alpha inhibitors ADRs mycobacterial, fungal, opportunistic infectious complications (sepsis, TB), rash, HA, nausea, cough, lymphoma; infliximab causes cardiac side effects; test for TB before starting TNFalphas
Kineret ADRs increase risk of infections, injection site reactions, HA, nausea, diarrhea, sinusitis, flu-like symptoms, ab pain
Created by: cytoskeletor
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