What is the primary function of the cerebellum

To detect the difference or "motor error" between the intended movement and the actual movment

Purkinje cells are GABAergic. They are the only source of output from the cerebellum

Axons from the pontine nuclei are called mossy fibers.

Where do mossy fibers relay their information to?

The contralateral cerabellar cortex. They synapse on neurons in the deep cerebellar nuclei, and on granule cells in the granule layer of the cererbal cortex.

What are the axons of granule cells called, and where do they go?

Parallel fibers. They ascend to the molecular layer of the cerebellar cortex

What do parallel fibers synapse onto? Is this connection excitatory or inhibitory?

They form T-shaped excitatory synapses with the dendrites of Purkinje cells.

True or false: Parallel fibers are the same thing as purkinje cells.

False. Parallel fibers are just the axons of granule cells.

What are climbing fibers?

Climbing fibers are the axons of the cells arising from the inferior olive.

What do climbing fibers do?

Climbing fibers directly modulate input to purkinje cells

True or false: The Sole output of the cerebellum is excitatory

False. Purkinje cells are the only source of output and they are inhibitory.

Where are golgi cells located, and what do they do?

They are found in the molecular layer. They receive input from parallel fibers, and provide inhibitory feedback to granule cells.

When does LTD happen?

LTD happens when both climbing fibers and parallel fibers are activated at the synapses with Purkinje cells.

What happens as a result of LTD?

There is a reduction in the efficacy of parallel fiber input to purkinje cells. This weakens the influence of the inhibitory loop by increasing the response of neurons in the deep cerebellar nuclei to afferent activity

Plasticity in the cerebellum happens as a result from what?

Reductions in the purkinje cell responses to parallel fiber inputs.

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True or false: the cerebellum sends prominent projections to virtually all circuits that govern lower motor neurons

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Cerebellum & Mvmt

Modulation of movement by the cerebellum

Question	Answer
True or false: the cerebellum sends prominent projections to virtually all circuits that govern lower motor neurons	False. They send prominant projections to virtually all circuits that govern Upper motor neurons
Projections TO the cerebellum come from the	Cerebral cortex. The project to both the cerebellar cortex and the deep nuclei
Projections FROM the cerebellum come from	the deep cerebellar nuclei
What is the primary function of the cerebellum	To detect the difference or "motor error" between the intended movement and the actual movment
Purkinje Cells	Purkinje cells are GABAergic. They are the only source of output from the cerebellum
Mossy fibers	Axons from the pontine nuclei are called mossy fibers.
Where do mossy fibers receive their projections from?	The cerebral cortex
Where do mossy fibers relay their information to?	The contralateral cerabellar cortex. They synapse on neurons in the deep cerebellar nuclei, and on granule cells in the granule layer of the cererbal cortex.
What are the axons of granule cells called, and where do they go?	Parallel fibers. They ascend to the molecular layer of the cerebellar cortex
What do parallel fibers synapse onto? Is this connection excitatory or inhibitory?	They form T-shaped excitatory synapses with the dendrites of Purkinje cells.
True or false: Mossy fibers from the pontine nuclei synapse with granule cells, whose axons (parallel fibers) synapse with purkinje cells	True.
True or false: Parallel fibers are the same thing as purkinje cells.	False. Parallel fibers are just the axons of granule cells.
What are climbing fibers?	Climbing fibers are the axons of the cells arising from the inferior olive.
What do climbing fibers do?	Climbing fibers directly modulate input to purkinje cells
True or false: The Sole output of the cerebellum is excitatory	False. Purkinje cells are the only source of output and they are inhibitory.
Where are golgi cells located, and what do they do?	They are found in the molecular layer. They receive input from parallel fibers, and provide inhibitory feedback to granule cells.
When does LTD happen?	LTD happens when both climbing fibers and parallel fibers are activated at the synapses with Purkinje cells.
What happens as a result of LTD?	There is a reduction in the efficacy of parallel fiber input to purkinje cells. This weakens the influence of the inhibitory loop by increasing the response of neurons in the deep cerebellar nuclei to afferent activity
What does the formation of LTD seem to be?	A motor learning process
Plasticity in the cerebellum happens as a result from what?	Reductions in the purkinje cell responses to parallel fiber inputs.

Created by: 795853265

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