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P1, top 200, grp 1

Top 200 - Group 1

BrandGenericClassIndicationDose FormRouteAdult DosingPediatric DosingMOA
Lopressor Metoprolol Tartrate Beta Blocker HTN, MI Tablets: 25, 50, 100mg IV: 5mg/5ml Oral, IV HTN: IR: 100-450mg QD or divided MI: Early: inject 3 bolus of 5mg in 2 min intervals >15mins: 25-50mg PO Q6’ x48 hr Late: 100mg BID x3 mos N/A Blocks beta receptors, primarily affecting CV system (decreases heart rate, contractility, and BP) and lungs (promotes bronchospasm)
Toprol XL Metoprolol Succinate Beta Blocker HTN, Angina Pectoris, HF Tablets: 25, 50, 100, 200mg Oral HTN: 25-200mg QD; 400mg max 6-16 YO: 50-200mg QD Blocks beta receptors, primarily affecting CV system (decreases heart rate, contractility, and BP) and lungs (promotes bronchospasm)
Lotensin Benazepril Ace Inhibitor HTN Tablets: 5, 10, 20, 40mg Oral 20-40mg QD-BID; max 80mg/day >6 YO: 0.1-0.6mg/kg QD; max 40mg/day Stops angiotensin converting enzyme to reduce BP
Prinivil; Zestril Lisinopril Ace Inhibitor HTN, HF, MI Tablets: 2.5, 5, 10, 20, 30, 40mg Oral HTN: 20-40mg QD; max 80mg/day HF: 5-20mg QD (Prinivil) or 5-40mg QD (Zestril) Acute MI: 10mg QD >6 YO: 0.07mg/kg QD; max 5mg/day Stops angiotensin converting enzyme to reduce BP
Vasotec Enalapril Ace Inhibitor HTN, HF, Asymptomatic left ventricular dysfunction Tablets: 2.5, 5, 10, 20mg IV: 1.25mg/ml Oral, IV HTN: 5-40mg QD or divided IV: 1.25mg Q6’ over 5 min period HF: 2.5-20mg BID ALVD: 2.5mg BID 1 mo-16 YO: 0.08mg/kg QD; max 5mg/day Stops angiotensin converting enzyme to reduce BP
Cardizem; Cardizem CD; Cardizem LA; Cartia XT; Dilt XR; Matzim LA; Taztia XT; Tiazac Diltiazem Calcium Channel Blocker HTN, Angina, Paroxysmal Supraventricular Tachycardia (PSVT) SR Caps (BID): 60, 90, 120mg ER Caps (QD): 120, 180, 240, 300, 360, 420mg IR Tabs: 30, 60, 90, 120mg ER Tabs (Cardizem LA): 120, 180, 240, 300, 360, 420mg IV Soln: 5mg/ml Oral, IV HTN: ER Caps: 120-490mg QD ER Tabs: 120-540mg QD Angina: ER Caps: 120-480mg QD ER Tabs: 180mg BID PSVT: 5-10mg/hr; increase in 5mg/hr increments up to 15mg/hr maintained for up to 24 hrs N/A Block calcium channels to control the heart rate/decrease BP
Calan; Calan SR; Verelan; Verelan PM Verapamil SR Calcium Channel Blocker HTN, Angina, PSVT Tablets Oral Calan: 40-120mg 3-4 times/day Isoptin: 120-240mg QD-BID (400mg max) N/A Block calcium channels to control the heart rate/decrease BP
Norvasc Amlodipine Calcium Channel Blocker Prophylaxis, Stable Angina, Variant Angina Tablets: 2.5, 5, 10mg Oral 5-10mg QD 6-17 YO: 2.5-5mg QD Block calcium channels to control the heart rate/decrease BP
Imdur; Isordil; Titradose; Dilatrate SR; IsoDitrate ER Isosorbide Mononitrate; Isosorbide Dinitrate Nitrate HTN, Angina Tablet Oral 20-40mg QD N/A Organic nitrate that relaxes vascular smooth muscle resulting in dilation of peripheral arteries & veins
Digitek; Lanoxin; Digox Digoxin Cardiac Glycoside HF, Atrial Fibrillation Tablet, IV Soln Oral, IV AF: initial: 25mg IV/orally Q2’ (max 1.5mg) Maintenance: 0.125-0.375mg IV/oral HF: 2.4-3.6 mcg/kg IV/IM HF: 1.9-3.1 mcg/kg IV/IM BID Inhibits Na+/K+ ATPase, which increases intracellular Na+ concentration leading to increased intracellular Ca2+ concentration
Humira Adalimumab Tumor Necrosis Factor Inhibitor (Monoclonal Antibodies) (Antirheumatic) Crohn’s Disease, Juvenile Idiopathic Arthritis, Plaque Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis Injection Soln. SubQ 40mg every other week Ulcerative Colitis: 160mg subQ on day 1, followed by 80mg subQ 2 weeks later 4 YO: 15-<30kg: 20mg every other week >30kg: 40mg every other week Binds and inactivates tumor necrosis factor (TNF) suppressing inflammatory and immune response
Remicade Infliximab Immunological Agent Crohn’s Disease, Psoriasis, Rheumatoid Arthritis Injection Soln. IV 5mg/kg IV over at least 2 hrs given at week 0, 2, and 6, then every 6 weeks thereafter 6 YO+: 5mg/kg IV over at least 2 hrs given at week 0, 2, and 6 followed by maintenance therapy IgG that binds to TNF-alpha and neutralizes biological activity
Enbrel Etanercept Immune Suppressant Rheumatoid Arthritis, Juvenile Arthritis Injection Soln. SubQ 25-100mg subQ every week (can be divided, but doses need not be 72-96 hrs apart) 2 YO+: 0.8mg/kg subQ once a week (50mg/week max) Binds and inactivates TNF suppressing inflammatory and immune response
Avapro Irbesartan ARB HTN, Diabetic Nephropathy, Proteinuria Tablets: 75, 150, 300 mg Oral HTN: 150-300mg QD (75mg for volume depleted pts) Nephropathy w/T2DM: 300mg QD N/A Blocks binding site of angiotensin II to AT1 receptor producing a decrease in BP
Cozaar Losartan ARB HTN, Diabetic Nephropathy Tablets: 25, 50, 100mg Oral Initial dose for both = 50mg HTN: 25-100mg QD-BID Nephropathy w/T2DM & HTN: 100mg QD >6 YO: 0.7mg/kg QD 50mg max Blocks binding site of angiotensin II to AT1 receptor producing a decrease in BP
Benicar Olmesartan ARB HTN Tablets: 5, 20, 40mg Oral 20-40mg QD 6-17 YO: 10-20mg QD if <35kg; 20-40mg if >35kg Blocks binding site of angiotensin II to AT1 receptor producing a decrease in BP
Diovan Valsartan ARB HTN, Heart Failure, Myocardial Infarction (MI) Tablets: 40, 80, 160, 320mg Oral HTN: 80-320mg QD HF: 40mg BID  80-160mg = 320mg max MI: 160mg BID 6-16 YO: initial: 1.3mg/kg QD (max = 40mg/day) Blocks binding site of angiotensin II to AT1 receptor producing a decrease in BP
Bystolic Nebivolol Beta Blocker HTN Tablets: 2.5, 5, 10, 20mg Oral Initial: 5mg QD leading to 40mg QD N/A Blocks beta-1 receptors, primarily affecting heart (slows rate), vascular system (decreases BP), and, to lesser extent, lungs (reduces function)
Tenormin Atenolol Beta Blocker HTN, MI, Angina Pectoris Tablets: 25, 50, 100mg IV: 0.5mg/ml Oral, IV 25-100mg QD or 50mg BID N/A Blocks beta-1 receptors, primarily affecting heart (slows rate), vascular system (decreases BP), and, to lesser extent, lungs (reduces function)
Coreg; Coreg CR Carvedilol Beta Blocker HTN, MI, HF IR Tablets: 3.125, 6.25, 12.5, 25mg CR Capsules: 10, 20, 40, 80mg Oral IR: 3.125-12.5mg BID CR: 10-80mg QD N/A Blocks alpha-1 receptors & nonselective beta receptors to decrease BP
Created by: Ryan Stocks
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