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Bio Ch 15

QuestionAnswer
“Omnis cellula e cellula” Every cell originates from another cell
All organisms produced by a series of repeated rounds of? cell growth and division
In eukaryotes, cell division via? mitosis and meiosis
field of genetics involving microscopic examination of chromosomes and cell division Cytogenetics
When cells get ready to divide, the chromosomes become? compact
reveals number, size, and form of chromosomes in an actively dividing cell Karyotype
Humans have how many pairs of chromosomes? 23
22 pairs in humans Autosomes
1 pair in humans – XX or XY Sex chromosomes
humans have 23 pairs of chromosomes Diploid or 2n
gametes have 1 member of each pair of chromosomes or 23 total chromosomes Haploid or n
In diploid species, members of a pair of chromosomes are called? homologues
each homologue nearly identical in size and genetic composition Autosomes
Both carry gene for eye color but one may have brown and the other blue example of autosome
X and Y very different from each other in size and composition Sex chromosomes
first gap G1
synthesis of DNA S
second gap G2
mitosis and cytokinesis M
G1, S, and G2 are? Interphase
substitutes for G1 for cells postponing division or never dividing again G0
Cell growth occurs during what phase? G1
Chromosomes replicate in what phase? S
After replication, two copies stay joined to each other and are called? sister chromatids
Human cell in G1 has how many chromosomes? 46
needed during mitosis and cytokinesis Cell synthesizes proteins
Division of one cell nucleus into two, with separation of sister chromatids Mitosis
follows mitosis to divide the cytoplasm into two daughter cells Cytokinesis
External factors in the decision to divide? Environmental conditions; Signaling molecules
Internal factors in the decision to divide? Cell cycle control molecules; Checkpoints
responsible for advancing a cell through the phases of the cell cycle Cyclins or cyclin-dependent kinases (cdks)
are kinases controlling cell cycle Cdks (Must bind to a cyclin to be active)
Three checkpoints in eukaryotes? -G1 checkpoint (restriction point) -G2 checkpoint -Metaphase checkpoint
Checkpoint proteins act as what to determine if the cell is in proper condition to divide? sensors
Loss of checkpoints can lead to? mutations and cancer
in Mitotic Cell Division, cell divides to produce? two new cells genetically identical to the original
Original cell is mother cell, new are? daughter cells
Mitotic Cell Division involves? mitosis plus cytokinesis
Used for asexual reproduction or for development and growth of multicellular organism Mitotic Cell Division
two identical copies with associated proteins Sister chromatids
When preparing for cell division, chromatids tightly associated at? centromere
Ensures that each daughter cell will obtain the correct number and types of chromosomes Mitotic spindle
responsible for organizing and sorting the chromosomes during mitosis Mitotic spindle apparatus (or mitotic spindle)
mitotic spindle composed of? microtubules
Microtubule organizing center (MTOCs) Centrosomes
Animal cells have centrioles, other eukaryotes don’t (True of False) True
Centrosomes duplicates at the beginning of what phase? M
Spindle formed from? microtubules
Microtubules formed from? tubulin proteins
Three types of microtubules? Astral, Polar, Kinetochore
position spindle in cell Astral microtubules
separate two poles Polar microtubules
attached to kinetochore bound to centromeres Kinetochore microtubules
phase of the cell cycle during which the chromosomes are decondensed and found in the nucleus (G1, S, G2) Interphase
Phases of mitosis (in order) -Prophase -Prometaphase -Metaphase -Anaphase -Telophase
division into two daughter cells Cytokinesis
-Chromosomes have already replicated and are joined as pairs of sister chromatids -Nuclear membrane dissociates into small vesicles -Chromatids condense into highly compacted structures that are readily visible by light microscopy Prophase
Nuclear envelope completely fragments Mitotic spindle is fully formed Centrosomes move apart Spindle fibers interact with sister chromatids Two kinetochores on each pair of sister chromatids are attached to kinetochore microtubules from opposite poles Prometaphase
-Pairs of sister chromatids are aligned along a plane halfway between the poles -Organized into a single row -When this alignment is complete, the cell is in this phase Metaphase
Pairs of sister chromatids are aligned along a plane halfway between the poles called the? metaphase plate
-Connections broken between sister chromatids -Kinetochore microtubules shorten, pulling chromosomes toward the pole to which they are attached -Poles move away from each other as overlapping polar microtubules lengthen and push against each other Anaphase
-Chromosomes have reached their respective poles and decondense -Nuclear membranes now re-form to produce two separate nuclei Telophase
In most cases, mitosis is quickly followed by? cytokinesis
Two nuclei are segregated into separate daughter cells Cytokinesis
cleavage furrow constricts like a drawstring to separate the cells Cytokinesis in Animals
cell plate forms a cell wall between the two daughter cells Cytokinesis in Plants
Sexual reproduction requires a fertilization event in which two haploid gametes unite to create a diploid cell called a? zygote
the process by which haploid cells are produced from a cell that was originally diploid Meiosis
Like mitosis, meiosis begins after a cell has progressed through what phases? G1, S, and G2
Two key differences in meiosis? (vs mitosis) 1. Homologous pairs form a bivalent or tetrad 2. Crossing over
Homologous pairs of sister chromatids associate with each other, lying side by side to form a? bivalent or tetrad
Homologous pairs of sister chromatids associate with each other, lying side by side to form a bivalent or tetrad. This is what process? synapsis
a protein structure that connects homologous chromosomes Synaptonemal complex
-Physical exchange between chromosome pieces of the crossing bivalent -May increase the genetic variation of a species Crossing over
arms of the chromosomes tend to separate but remain adhered at a crossover site Chiasma
chromosomes condense, bivalents form and the nuclear membrane breaks down Prophase I
-spindle apparatus complete, chromatids attach to kinetochore microtubules -Pairs of sister chromatids attached to single pole Prometaphase I
bivalents organized along metaphase plate as double row Metaphase I
segregation of homologues occurs Anaphase I
sister chromatids have reached their respective poles and decondense and nuclear membranes reform Telophase I
two haploid cells, with no pairs of homologous chromosomes End of meiosis I
No S phase between? meiosis I and meiosis II
Sister chromatids separated in? anaphase II, unlike anaphase I
Sorting events of meiosis II are similar to those of? mitosis
Mitosis produces? two diploid daughter cells that are genetically identical (ex: 6 chromosomes in 3 homologous pairs)
Meiosis produces? four haploid daughter cells (ex: Each daughter has random mix of 3 chromosomes)
Sequence of events that produces another generation of organisms Sexual life cycle
involves an alternation between haploid cells or organisms and diploid cells or organisms Sexual life cycle for sexually reproducing organisms
Most animal species are? diploid
are a specialized type of cell Haploid gametes
unite to form diploid zygote, then proceed immediately through meiosis to make four haploid spores Haploid cells
Haploid-dominant species? Many fungi and some protists Multicellular organism
Multicellular diploid organism sporophyte
Multicellular haploid organism gametophyte
Variations in chromosome structure and number can have? major effects on organisms
Between species is it normal for structure and number of chromosomes to vary? yes
Chromosome composition within a given species tends to remain? relatively constant
2 sets of 23 chromosomes (total of 46) Humans
2 sets of 39 chromosomes (total of 78) Dog
2 sets of 4 chromosomes (total of 8) Fruit fly
2 sets of 12 chromosomes (total of 24) Tomato
Chromosome identification through? Size, location of centromere, banding pattern
centromere at the end Telocentric
centromere near end Acrocentric
centromere off center Submetacentric
centromere middle Metacentric
short arm of chromosome is? p
long arm of chromosome is? q
Segment of chromosome missing Deletions
Repeated segment of chromosome Duplications
A segment has a change in direction along a single chromosome (can break genes at ends or separate from regulatory regions) Inversions
One segment becomes attached to another chromosome May be simple or reciprocal Translocations
the normal number of chromosomes (In a diploid organism, two sets is normal) Euploid
3 or more sets of chromosomes Polyploid
Abnormal number of a particular chromosome Aneuploidy
Missing one of normal copies of a chromosome Monosomic
Normal 2 copies of a chromosome plus a 3rd Trisomic
-Chromosomes do not sort properly during cell division -During meiosis can produce aneuploid gametes (too many or too few chromosomes) Nondisjunction
In animals, deviations from diploidy are usually? lethal
Plants commonly exhibit? polyploidy
Trisomic and monosomic individuals have? an imbalance in the level of expression of genes on different chromosomes that interact in the cell (disrupts cell function)
Created by: lnharrold
 

 



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