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rsrch pharm test 2
2 anti-infectives
PENICILLIANS | BETA-LACTAMS | CEPHALOSPORINS | TETRACYCLINES | Gentamicin (Gramycin) | QUINOLONES (flouroquinolones) | Ciproflaxacin (Cipro) |
---|---|---|---|---|---|---|
amoxicillin (Amoxil), penicillin V potassium (Pen-Vee K) | (blank) | (blank) | (blank) | (blank) | (blank) | (blank) |
amoxicillin (Amoxil), penicillin V potassium (Pen-Vee K) | 4 sub-classes; 1. penicillians 2. cephalosporins 3. carbapenems,4. monobactams. | Cefazolin sodium (Andef, Kefzol, ceftriaxon (rocephin, cephalexin (Keflex) | Doxcycycline | aminoglycoside | cipro | flouroquinolones |
gram + bacteria; staphlococcus | break down chemical bond between Carbon and Nitrogen | 3 generations 1st - gram + coverage; 2nd gen- both; 3rd gen- gram - coverage 4th gen. cefapime | contraindicated in peds b/c of mild interaction | toxic to ears and kidney | very potent broad spectrum- kill bacterial by altering DNA gyrase | For the treatment of infections caused by susceptible gram-negative bacteria, including E. coli, |
SE- uticaia, puritis & andioeduam | betalactamase- enzyme produced by bacteria strains that makes bacteria more resistant | (antibiotic structurally related to penicillins | SE-discloation of permananet teeth, hypoplasia in fetus and children; possible retard of skeltal dev, and photosensitivity | bind to ribosomes (30S) and prevent protien sythesis of bacteria | interact with antacids, iron & zink | CNS: Headache, dizziness, insomnia, fatigue, somnolence, depression, blurred vision CV: Arrhythmias, hypotension, angina EENT: Dry eye, eye pain, keratopathy GI: Nausea, vomiting, dry mouth, diarrhea, abdominal pain |
most common adverse reaction- urticaria, pruritis angioedma | (blank) | 3rd generation - cefoxitin & ceftazidime | coadminstration with milk, antacids, iron salts may decrease oral absoprtion of --CI preganant /lactating women and pediatric patients | tx of gram negative | (blank) | (blank) |