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Antibiotics 411
Antibiotics
Question | Answer |
---|---|
Systemic infection in which pathogens are present in the circulating bloodstream | Septicemia |
Syndrome involving multiple system organ involvement that is a result of microorganisms or their toxins circulating in the blood | Sepsis |
Invasion of body by pathogenic microorgs that reproduce and multiply, causing disease | Infection |
Localized presence and multipication of microorgs w/out invasion or damage | Colonization |
Presence of viable bacteria in the blood | Bacteremia |
Staphylococcus category | Gram-positive cocci |
Streptococcus category | Gram-positive cocci |
Escherichia coli category | Enteric gram-negative Bacilli |
Haemophilus influenza category | Gram-negative Bacilli |
Pseudomonas category | Gram-negative Bacilli |
Mycobacterium category | Acid-Fast Bacilli (AFB) |
Aqueous penicillin G | Natural penicillin, gm+ anaerobes |
Procain pen G | Natural penicillin, gm+ anaerobes |
Benzathine pen G | Natural penicillin, gm+ anaerobes |
Oxacillin | Penicillinase resistant, penicillinase producing gm+ orgs |
Nafcillin | Penicillinase resistant, penicillinase producing gm+ orgs |
Dicloxacillin | Penicillinase resistant, penicillinase producing gm+ orgs |
Cloxacillin | Penicillinase resistant, penicillinase producing gm+ orgs |
Ampicillin, Ampicillin/sulbactam | Aminopenicillin (Extended Spectrum), same gm+ as pen G, some gm- (E. coli, H. flu) |
Amoxicillin, Amoxicillin/clavulanate | Aminopenicillin (Extended Spectrum) Same gm- as pen G, some gm- (E. coli, H. flu) |
Carbenicillin | Antipseudomonal Penicillin, pseudomonas |
Ticarcillin | Antipseudomonal Penicillin, pseudomonas |
Piperacillin, Piperacillin/tazobactam | Antipseudomonal Penicillin, pseudomonas |
Cephalexin | Cephalosporins-1st gen, gm+, little gm-, no H. flu, no B. fragilis |
Cephradine | Cephalosporins-1st gen, gm+, little gm-, no H. flu, no B. fragilis |
Cefadroxil | Cephalosporins-1st gen, gm+, little gm-, no H. flu, no B. fragilis |
Cefaclor | Cephalosporins-2nd gen, same gm+ as 1st gen, addit gm- (H. flu) |
Cefuroxime axetil | Cephalosporins-2nd gen, same gm+ as 1st gen, addit gm- (H. flu) |
Cefprozil | Cephalosporins-2nd gen, same gm+ as 1st gen, addit gm- (H. flu) |
Loracarbef | Cephalosporins-2nd gen, same gm+ as 1st gen, addit gm- (H. flu) |
Cefixime | Cephalosporins-3rd gen, more gm-, less gm+, moderate against pseudomonas |
Cefpodoxime | Cephalosporins-3rd gen, more gm-, less gm+, moderate against pseudomonas |
Ciprofloxacin | Fluoroquinolones, excellent gm- (H. flu), decent gm+, excellent shigella & salmonella |
Ofloxacin | Fluoroquinolones, excellent gm- (H. flu), decent gm+, excellent shigella & salmonella |
Lomefloxacin | Fluoroquinolones, excellent gm- (H. flu), decent gm+, excellent shigella & salmonella |
Trovafloxacin | Fluoroquinolones, excellent gm- (H. flu), decent gm+, excellent shigella & salmonella |
Gatifloxacin | Fluoroquinolones, excellent gm- (H. flu), decent gm+, excellent shigella & salmonella |
Erythromycin | Macrolides, gm+, gm- (H. flu), genital pathogens |
Clarithromycin | Macrolides, gm+, gm- (H. flu), genital pathogens |
Azithromycin | Macrolides, gm+, gm- (H. flu), genital pathogens |
Tetracycline | Tetracyclines, gm+, gm-, acne |
Metronidazole (Flagyl) | Misc, gm+ and gm- anaerobes |
Clindamycin | Misc, gm+ and gm- aerobes and anaerobes (better than Flagyl against), protozoa |
SMX-TMP | Misc, gm+ and gm- aerobes, chlamydia, protozoa, UTI & PCP infections |
Imipenem/cilastin | Carbapenems, wide spectrum, powerful |
Aztreonam | Monobactams, powerful gm-, high resistance |
Vancomycin | Glycopeptides, powerful gm+, high resistance |
Teicoplanin | Glycopeptides, powerful gm+, MRSA |
Gentamicin | Aminoglycosides, powerful gm-, low resistance |
Tobramycin | Aminoglycosides, powerful gm-, low resistance |
Gentamicin & Tobramycin (Aminoglycosides) toxicity | otoxicity, nephrotoxicty |
Natural Penicillins Spectrum | Gm+ anaerobes |
Penicillinase resistant spectrum | penicillinase producing gm+ |
Amonopenicillin (Extended Spectrum) spectrum | Same Gm+ as pen G, Gm- (salmonella, shigella, some E. coli, & H. flu) |
Antipseudomonal Penicillin spectrum | Pseudomonas (gm-) |
Cephalosporins-1st gen spectrum | gm+, little gm-, no H. flu, no B. fragillis |
Cephalosporins-2nd gen spectrum | same gm+, addit gm- (H. flu) |
Cephalosporins-3rd gen spectrum | gm-, less gm+, moderate against pesudomonas |
Fluoroquinolones spectrum | excellent gm- (H. flu), decent gm+, shigella, salmonella |
Macrolides spectrum | gm+, gm- (H. flu), genital pathogens, others: MAC, legionella, mycoplasma pneumonia, helicobacter pylori |
Tetracyclines spectrum | decent gm+ and gm-, acne |
Metronidazole spectrum | gm+ and gm- anaerobes |
Clindamycin spectrum | gm+ and gm- anaerobes (better) and aerobes, protozoa |
SMX-TMP spectrum | gm+ and gm- aerobes, chlamydia, protozoa, *UTIs, PCP* |
Carbapenems/Imipenem/cilastin spectrum | wide, powerful, high resistance |
Monobactams/Aztreonam spectrum | powerful gm-, high resistance |
Glycopeptides/Vancomycin & Teicoplanin spectrum | powerful gm+, MRSA |
Aminoglycosides/Gentamicin & Tobramycin spectrum | powerful gm-, low resistance |
Oxacillin, Nafcillin, Dicloxacillin, Cloxacillin | Penicillinase resistant, penicillinase producing gm+ orgs |
Ampicillin, Amoxicillin | Aminopenicillin, gm+ and gm- (more gm-) |
Carbenicillin, Ticarcillin, Piperacillin | Antipseudomonal Penicillins |
Cephalexin, Cephradine, Cefradoxil | 1st gen Cephalosporins, gm+. little gm-, no H. flu, no B. fragilis |
Cefaclor, Cefuroxime axetil, Cefprozil, Loracarbef | Cephalosporins-2nd gen, same gm+ as 1st gen, addit gm- (H. flu) |
Cefixime, Cefpodoxime | Cephalosporins-3rd gen, gm-, less gm+ |
Imipenem/cilastin | Carbapenem |
Axtrepnam | Monobactam, gm- |
Vancomycin, Teicoplanin | Glycopeptides, gm+, MRSA |
Gentamicin, Tobramycin | Aminoglycosides, gm- |