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Alphaherpesvirinae
Marek's Disease
| Question | Answer |
|---|---|
| What are four other names for this disease? | (1)Fowl paralysis. (2)Range paralysis. (3)Polyneuritis. (4)Neurolymphomatosis |
| There are four different variations of the serotypes. What are they? | Mild, Virulent, Very virulent, and Very virulent plus |
| Why is a cell-free infectious virus almost impossible to obtain? Only obtained in dander from feather follicles. | The virus is slowly cytopathic and remains highly cell associated (macrophage-associated) |
| How is this HIGHLY CONTAGIOUS disease transmitted? | Cell-free virus is released as dander and can survive in house dust and litter for several months. Infection is by inhalation of the contaminated dust or chicken dander. |
| T/F. Vertical transmission (by egg) has been reported. | FALSE |
| What is the most common pathogenesis? | Subclinical infection with virus shedding |
| There are 3 phases of in vivo infection. What is the first phase? | (1)Productive infection:virus replication in the EC of the URT causes a macrophage-associated viremia...virus goes to lymphoid organs and causes a transient productive infection in B cells and B cell cytolysis |
| What is the second and third phase of the infection? | (2)Latent infection: activated T cells and accounts for long-term carrier state. (3)Neoplastic transformation:lesions result from the infiltration and in situ proliferation of the transformed latently infected T lymphocytes |
| This disease is [?] with overlapping signs. Mortality can reach 80%. | PROGRESSIVE |
| What are the four types of lymphomatosis seen? | Neurolymphomatosis, Visceral, Ocular, and Cutaneous |
| Describe Neurolymphomatosis. | [Classial Marek's Disease]. Enlargement of one or more peripheral nerve trunks, show loss of striations, are edematous, gray or yellowish in appearance. UNILATERAL. Lameness, droopy wings, splayed legs, and limberneck. |
| Describe the ocular type. | graying of the iris ("grey eye", "cat's eye", "pearl eye") in one or both eyes due to T Cell infiltration...partial or TOTAL blindness |
| Describe the cutaneous type. | round, nodular lesions in the skin...plucking feathers results in the release of cell-free virus |
| How do you isolate the virus? | Buffy coat or spleen cells |
| What is the main method of control? | VACCINATION...specifically the avirulent turkey herpesvirus vaccine because it infects birds productively |
Created by:
lkollmeier
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