click below
click below
Normal Size Small Size show me how
MS
Question | Answer |
---|---|
What are the McDonald criteria for MS diagnosis? Which are indicative of CIS? | 2 attacks/2 lesions 2 attacks/1 lesion: (need evidence of dissemination in space) 1 attack/2 lesions: (need evidence of dissemination in time) 1 attack/1 lesion: (need evidence of both dissemination in time and space) Progressive course over 1yr |
How is dissemination in space determined? | MRI brain MRI spinal cord CSF Oligoclonal bands |
What is the difference between T1 and T2 weighted MRI? | T1 detects active inflammation T2 detects old and new lesions |
What type of evoked potential test is the only type proven useful in the diagnosis of MS? | Visual Evoked Potentials |
What are some markers in CSF that are consistent with immune-related conditions? | elevated IgG antibodies Presence of oligoclonal bands certain proteins common with the breakdown of myelin |
What are some visual changes that may occur with MS? | Optic neuritis, nystagmus, oscillopsia, intranuclear opthalmoplegia, optic disc pallor |
What do you call an increase in body temperature causing an increase in neurologic symptoms? | Uhthoff's phenomenon |
What are some broad signs and symptoms of MS? | motor weakness, spasticity, vision impairment, heat intolerance, fatigue, cerebellar dysfunction, urinary and bowel issues, cognitive impairment |
At which stages of the Expanded Disability Status Scale is a person with MS still ambulatory? | 0-4.5 |
Which stages of the EDSS is characterized by impairments in ambulation? | 5-9.5 |
What is stage 10 of EDSS? | death |
Name the phenotypes of MS | Primary progressive Secondary progressive Relapsing remitting Clinically isolated syndrome |
What is the most common type of MS? | Relapsing-remitting |
Name some negative prognostic factors with MS | PPMS older age at onset African American early cerebellar or pyramidal signs smoking low vitamin D levels |
What is the main goal of medication management of MS? | delay progression of disability |
What temp should the pool be to be appropriate for a person with MS? | 80-85deg |
What tests can be conducted to assess a person's ability to dual task? | TUG>14s TUG manual (holding a cup of water) >14.5 TUG cognitive (counting backwards by 3s) >15s >4.5s difference between TUG manual and TUG is indicative of impairment |
What is the cutoff score for DHI in MS indicating increased fall risk? | >59 (out of 0-100) |
Is the BBB intact or impaired in those with MS? | impaired |
What is the reduction in life expectancy in a person with MS? | 7-14yrs |
What comorbidities are more common in those with MS? | sepsis cancer ischemic stroke ulcerative colitis attempted suicide |
What are the most prevalent comorbidities in those with MS? | depression anxiety HTN HLD chronic lung disease |
What are the most prevalent autoimmune diseases with MS? | psoriasis thyroid disease |
What are the most prevalent cancers with MS? | breast cervical digestive system |
What type of MS: 1st episode of demyelination in the CNS that could become MS if additional activity occurs? | clinically isolated syndrome |
The most common type of MS with discrete attacks followed by remission. | relapsing remitting |
Progressive accumulation of disability after an initially relapsing course. | Secondary progressive |
Nearly continuous worsening of disease onset without distinct attacks. | Primary progressive |
How long must symptoms last for it to count as a relapse or exacerbation? | >24 hours new, recurrent, or worsening symptoms and cannot be attributed to another etiology |
If symptoms last <24 hours or experiencing Uhthoff's phenomenon what is it called? | pseudoexacerbation |