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Pharmacology
Chapter 8 Drugs Used in GI Disorders
Question | Answer |
---|---|
What are the functions of the GI system? | intake of food & fluid into the body; absorption of nutrients and fluid; excretion of waste products |
Describe the basic structures of the GI system. | Mouth, teeth, tongue, salivary glands, esophagus, outpocketings of esophagus, stomach, liver, pancreas, duodenum, jejunum, ileum, cecum, colon, rectum, anus. |
Define monogastric. | One stomach; no outpocketings or forestomachs. Carnivorous animals. |
Describe the ruminant GI system. | three forestomachs (reticulum, rumen, omasum); one true stomach (abomasum). |
What is hindgut fermentation? | Equines, rabbits, and some rodents; monogastric GI configuration with a large cecum capable of limited roughage digestion. |
Describe the mechanisms of control in the GI system. | ANS--stimulation of parasympathetic portion increases GI activity; sympathetic stimulation decreases GI activity; stimulation of intrinsic receptors may cause peristaltic activity. GI hormones exert control over many functions; specialized cells. |
What is the veterinary term for vomiting? | Emesis. |
What is diarrhea? | the passage of loose or liquid stools, often with increased frequency. |
What drugs induce vomiting? | apomorphine, xylazine, hydrogen peroxide. |
What drugs inhibit vomiting? | antiemetics; chlorpromazine, prochlorperazine, antihistamines (for motion sickness or inner ear abnormalities). |
List the types of antiulcer medications used in veterinary medicine. | H2 receptor antagonists--cimetidine, ranitidine, famotidine; proton pump inhibitors--increase stomach pH; antacids--decrease hydrochloric acid levels in stomach (affect absorption of other drugs like cimetidine, digoxin, captopril, tetracycline, etc. |
What causes diarrhea? | hypersecretion, increased permeability, osmotic overload, altered intestinal motility, parasitism. |
List medications used to control diarrhea. | narcotic analgesics--increase segmental contractions, decrease secretions, enhance absorption; anticholinergics/antispasmodics--use w/ caution protectants/adsorbents--coating action protects inflamed mucosa/prevent absorption. |
List the categories of laxatives & their actions. | saline/hyperosmotic-hold water in GI tract (softens stool & stimulates stretch receptors); bulk producing--absorb water & swell (stimulates peristalsis); lubricants soften fecal mass; surfactants allow water to penetrate contents. |
What are dopaminergic antagonists? | They are GI prokinetics that block dopamine at the receptor, which stimulates GI motility of the gastroesophageal sphincter, stomach & small intestine. |
What are serotoninergic drugs? | They stimulate the motility of the proximal and distal GI tract and promote gastric emptying. |
What are direct cholinergics used for in treating GI disorders? | Postoperative treatment of ileus (retention of flatus or feces) and equine colic without obstruction. |
What do acetylcholinesterase inhibitors do? | increase the amount of acetylcholine available to bind smooth muscle receptors; used to treat rumen atony, stimulate GI motility, and curare overdose. |
Why are digestive enzymes used? | To treat pancreatic exocrine insufficiency. Pancrelipase contains enzymes aid in digestion of fats, proteins & carbohydrates. It is a powder mixed w/ food & allowed to stand 15-20 minutes before feeding. |
Discuss antibiotic use in GI disease. | Antibiotics are not routinely used because they may destroy normal GI flora and allow pathogenic bacteria to grow. Bloody diarrhea or sepsis may indicate need for antibiotics. |
What are antiinflammatory agents used for in GI disease? | To treat idiopathic inflammatory bowel disease in animals. |
List the categories of oral products. | Dentifrice & cleansing products--friskies feline diet; fluoride--CET flurafoam; perioceutic agents--doxirobe; tissue regeneration agents--consil dental; polishing paste--CET prophypaste; disclosing solution--Duo128. |