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ASCP
hematology
| Question | Answer |
|---|---|
| what cell shape is most commonly associated with idiopathic hemochromatosis | iron overload in tissue |
| a patient with polycythemia vera who is treated by phlebotomy is most likely to develop a deficiency of | iron |
| The direct antiglobulin test is often positive in | acquired hemolytic anemia |
| the hypoproliferative red cell population in the bone marrow of uremic patients is caused by | decreased levels of circulating erythropoietin |
| which of the following characteristics are common in H.spherocytosis, H. Elliptocytosis,H.stomatocytosis and paroxysmal nocturnal hemoglobinuria | red cell membrane defects |
| The most likely cause of the macrocytosis that often accompanies anemia of myleofibrosis is | folic acid deficiency |
| what is associated with megaloblastic anemia | neutropenia and thrombocytopenia |
| what type of polycythemia is severely burned patient most likely to have | relative polycythemia associated with dehydration |
| which of the following is seen in lead poisoning | basophilic stippling |
| Giant vacuolated, multi erythroid precursors are present in which | erythroleukemia |
| what is a significant feature of erythroleukemia/ acute erythroid leukemia(DiGuglielmo Syndrome) | megaloblastoid erythropoiesis |
| M:E ratio in erythroleulemia is usually | low |
| what is increased in erythrocytosis secondary to a congenital heart defect | erythropoietin |
| what is a characteristic of polycythemia vera | decreased or absent bone marrow stores |
| which of the RBC indices is a measure of the amount of hemoglobin in individual red blood cells | MCH |
| The RDW-CV and RDW-SD performed by automated cells counters are calculations that provide | an index of the distribution of RBC volumes |
| the laboratory tests performed on a patient indicate macrocytosis, anemia leukopenia and thrombocytopenia. what would the patient most likely have | vitamin B12 deficiency/ megaloblastic anemia |
| Wright -staine anema smear would most likely show | normocytic, hypochromic,erythrocytes |
| Evidence of active red cell regeneration may be indicated on a blood smear by | basophilic stippling, NRBC, polychromasia/accelerated heme synthesis |
| characteristics PB morphploogic feature in multiple myeloma is | rouleaux formation |
| in polycythemia vera, the hemoglobin, HCT, RBC count and red cell mass are | elevated |
| M;E ration in polycythemia vera sis usually | normal to slightly elevated |
| what is most closely associated with erythroleukemia | ringed sideroblasts, nuclear dudding and howell- jolly bodies |
| an increased amount of cytoplasmic basophilia in a blood cell indices indicates | decreased cytoplasmic maturation |
| the term shift to the left refers to | immature cell forms in PB |
| A term that means varying degrees of leukocytosis with a shift to the left and occasional NRBC in the PB | leukoerythroblastosis |
| Cells that produce antibodies and lymphokines | lymphocytes |
| The PB monocyte is an intermediate stage in the formation of the | fibroblast |
| specific (secondary )granules of the neutrophilic granulocyte | appear first at the myelocyte stage |
| Elevation of the total granulocyte count above 7.7x 10^3.ul(7.7x19^9/L) is termed | absolute neutrophilic leukocytosis |
| Elevation of the granulocyte percentage above 75% | relative neutrophilic leukocytosis |
| Elevation of the total white cell count above 12x10^3 is termed | leukocytosis |
| elevation of lymphocyte percentage above 47% | relative lymphocytosis |
| Terminal deoxynucleotidyl transferase (TdT) is a marker found on | lymphoblasts |
| Multipotent stem cells are capable of producing | lymphoid and myeloid stem cells |
| the phili chromsome is found by translocation between | long are chromosome 22 and long arm chromosome 9 |
| mechanism of cortisol- induced neutrophilia include | a shift in granulocytes from the marginating pool to the circulating pool |
| which cells are involved in immediate hypersensitivity reactions | basophils |
| feature of pernicious anemia | hypersegmentation |
| which of the following conditions is not associated with high incidence of leukemia | megaloblastic anemia |
| M;E ration in chronic myeloctyic leukemia is usually | high |
| in FAB classification, myelomonocytic leukemia would be | M4 |
| abnormalities found in erythroleukemia include | megaloblastoid development |
| neutropenia is not associated with | hodgkin disease |
| Auer rods are most likely present in | acute myelocytic leukemia |
| Dwarf or micro megakaryoctes may be found in the PB of patients with | myelofibrosis with myeloid metaplasia |
| which is associated with pseudo-pelger-huet anomaly | myelogenous leukemia |
| Auer bodies are | predominately found in acute myelogenous leukemia |
| the absence of the PH' chromosome in granulocytic leukemia suggest | rapid progression of the disease |
| Increased numbers of basophils are often seen in | chronic myelocytic leukemia |
| a hypercellular marrow with M;E ratio of 6;1 is most commonly due to | granulocytic hyperplasia |
| which is the most predominant form of secondary hematologic malignancy seen in patients with multiple myeloma | acute myelomonocytic leukemia |
| in chronic myelocytic leukemia, blood histamine concentrations tend to reflect the | number of basophils present |
| biochemical abnormalities characteristics of polycythemia vera include | increased serum B12 binding capacity |
| Auer rods | are lysosome and acid phosphatase positive |
| 50%-90% myeloblasts in a PB is typical in | acute myelocytic leukemia |
| The M: E ratio in acute myelocytic leukemia/AML is | high |
| most closely associated with chronic myelomonocytic leukemia | lysozymuria |
| the absence of intermediate maturing cells between the blast and mature neutrophil commony seen in acute myelocytic leukemia and myelodysplastic syndromes is called | leukemic hiatus |
| most closely associated with chronic myelogenous leukemia/CML | philadelphia chromosome |
| The bone marrow in the terminal stage of erythroleukemia is often indistinguishable from that seen in | acute myelocytic anemia |
| A block in the difference of maturation of, and an accretion of immature hematopoietic progenitors is a hallmark of | acute myelogenous leukemia |
| all stages of neutrophils are most likely to be seen in the peripheral blood of a patient with | chronic myelocytic leukemia |
| conditions of myeloproliferative disorders | myelocytic leukemia, polycythemia leukemia, idiopathic thrombocythemia |
| A patient has a tumor that concentrates erythropoietin. He is most likely to have which of the following types of polycythemia | poltcythemia associated with renal disese |
| what type of polycythemia is most often associated with emphesema | polycythemia,secondary to hypoxia |
| hemorrhage in polycythemia vere is result of | abnormal platelet function |
| a patient diagnosed with polycythemia 5 years ago NOW has a normal HCT,, decreased HBG and microcytic, hypochromic red cells. what is this cause | phlebotomy |
| in comparison to malignant lymphoma cells, reactive lymphocytes | are morphologically more variable throughout smear |
| T-cell acute lymphocytic leukemia (ALL) is closely related to | lymphoblastic lymphoma |
| ine the FAB classification, acute lymphocytic leukemia is divided into groups according to | morphology |
| increased levels of TdT activity are indicative of | acute lymphocytic leukemia |
| massive accumulation of primitive lymphoid- appearing cells in bone marrow is true for what | acute lymphoblastic leukemia (ALL) |
| the most common form of child hood leukemia | acute lymphocytic leukemia(ALL) |
| chronic lymphocytic leukemia is | accumulation of monoclonal B cells with a block in cell maturation |
| Hairy cells leukemia(leukemic reticuloendotheliosis) is | a chronic leukemia of lymphocytic origin |
| characteristics of hairy cell leukemia | pancytopenia,monoclear cells with ruffled edges,splenomgaly |
| increased resistance to infection is not a charateristic of what | hairy cell leukemia |
| morphologic variants of plasma cells include | flame cells, morula cells, grape cells |
| gaucher cells are not morphology of what cell | plasma cell variants |
| what favors the diagnosis of multiple myeloma | sheaths of immature plasma cells |
| what has a B cell origin | waldenstrom macroglobulinemia |
| most likely identified in lesions of mycosis fungoides | T lymphocytes |
| chronic lymphocytic leukemia cells are most likely to express which of the following cell surface markers | CD19,CD20,CD21,CD5 |
| which of the following markers typically detected in normal myeloid cells, are expressed on the surface of hairy cell leukemia lymphicyetes | CD11c |
| surface marker that is expressed in neoplastic plasma cells and is helpful in the diagnosis of myeloma is | CD138 |
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