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Immune Response
Advanced Patho
Question | Answer |
---|---|
Hypersensitivity 1 is mediated by | IgE |
HS 1 reaction common reactions | anaphylaxes, local, itching and sneezing, allergic rhinitis |
treatment for systemic HS 1 reaction | epinepherine |
What happens in HS 1 reaction | mast cell degranulation |
What is a HS 1 reaction | allergic reaction |
What is a HS 2 reaction | cytotoxic reaction |
What is HS2 mediated by | IgG IgM |
What does the HS2 do? | causes damage and altered fxn to tissue |
What is two common reactions with HS2 | Graves and blood incompatibility. |
Which HS reaction is organ specific | HS2- antibody binds to antigen on the cell surface |
what HS reaction is not organ specific | HS30 antibody binds to antigen OUTSIDE of cell surface and deposited in tissues from blood |
What is a HS3 reaction | immune complex reaction |
What. is the primary effector in HS3 | neutrophils |
What HS reaction is considered autoimmue | HS3 |
Two common types of HS3 | RA and Lupus. RA in joints and Lupus throughout body system and can be different |
What is a HS4 reaction | Cell mediated and delayed reaction |
What are HS4 primary mediators | T-cell lymphocytes |
Which HS reaction isnt related to anitbodies | HS4 |
What is a common HS4 reaction | contact dermatitis |
Which HS reaction is widely distributed with atopic dermatitis | HS1 |
Which HS reaction is at the site of contact | HS4 |
How do you treat atopic dermatitis | antihistimines and epinepherine |
How do you treat contact dermatitis | oral or topical steroids |
Which HS reaction is immediate | HS1 |
Which HS reaction is delayed | HS4 |
What is autoimmunity | Graves, lupus, RA |
What immunity has a familial association | Autoimmunity |
What is alloimunity | immune system reacts to tissue of OTHER member of same species |
What immunity is is transplant/transfusion reaction | alloimmunity |
What is primary immunodef | due to a single gene defect, something missing |
What is an example of primary immunodef | B-lymphocyte deficiency |
What is secondary immunodef | complication of other physiological condition |
What is an example of secondary immodef | HIV gets pneumocystits PNA, infection, chemo, |
What is the most common cause of secondary immodef | Malnutrition |
What is the first responders of immune system | Neutrophils |
inflammatory mediators such as histamine, leukotrienes, and prostaglandins do what? | vasodilation, bronchial smooth muscle contraction, and mucus production. |
what is the primary effector of HS2 | macrophages |
HS2 reactions | drug allergies, hemolytic anemia, blood transfusion mismatch with resulting transfusion reaction and Rh hemolytic disease. |
Common HS3 reaction | serum sickness, raynauds |
What happens in a HS3 reaction | Complex deposited in small peripheral vessels in cool temperatures leading to vasoconstriction and blocked circulation |
immune components can be involved in autoimmune diseases | T-Cells, B-cells and autoantibodies |