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pharmacology 2
Proton Pump Inhibitor Therapy
| Question | Answer |
|---|---|
| Which statement by the nursing student about the mechanism of action of proton pump inhibitors (PPIs) requires further intervention? | "PPIs work by blocking histamine2 receptors, which reduces gastric acid secretion." |
| In which time frame would a patient expect to experience effects from esomeprazole? | 1 Hour |
| Which statement regarding the pharmacodynamic profile of omeprazole is accurate? | The elimination half-life of omeprazole is 0.5 to 1 hour. |
| Which medical conditions would a nurse recognize that oral esomeprazole may be used to treat? | Gastroesophageal reflux disease (GERD) Duodenal ulcers Nonsteroidal antiinflammatory drug (NSAID)-induced ulcers Zollinger-Ellison syndrome |
| Which patients would a nurse determine require cautious use of or avoidance of esomeprazole? | A 70-year-old Asian patient with hypertension A 73-year-old Caucasian patient with osteoporosis A 29-year-old Hispanic patient who is breastfeeding A 54-year-old Caucasian patient with alcoholic cirrhosis |
| Which outcome would a nurse anticipate from the drug interaction that may occur in a patient who is receiving diazepam and has been newly prescribed omeprazole? | Increase in serum concentration of diazepam |
| patient who is receiving omeprazole has been prescribed clopidogrel following stent placement. Which outcome does a nurse alert the health care provider about resulting from the drug interaction? | Decrease in activation of clopidogrel |
| 93yr-old patient with GERD is prescribed esomeprazole. The patient is immobile in a skilled nursing facility, is frail, and experienced a stroke a year ago. Which adverse effects of esomeprazole will the nurse be concerned about in this patient | Dementia Pneumonia Osteoporosis Hip or vertebral fracture |