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33 Urinary Analgesic
Urinary Analgesic, Stimulant, and Antispasmodics
| Generic (Brand) | Route and Dosage | Uses and Considerations |
|---|---|---|
| bethanechol Cl (Urecholine, Duvoid, Urebeth) | A: PO: 10–50 mg t.i.d./q.i.d. 1 h a.c. or 2 h p.c.; max: 120 mg/dsubQ: 2.5-5 mg t.i.d./q.i.d. PRNC: PO: 0.2 mg/kg t.i.d. or0.6 mg/m2 t.i.dPregnancy category: C; PB: UK; t½: UK | For hypotonic or atonic bladder. Should not be taken if peptic ulcer is present. Can cause epigastric distress, abdominal cramps, nausea, vomiting, diarrhea, and flatulence. Can cause dizziness, lightheadedness, and fainting, especially when standing up |
| dimethyl sulfoxide (DMSO, Rimso-50) | Bladder instillation:50 ml of 50% sol retained for 15 min; repeat q2wk until relief | For cystitis. Administered into the bladder to remain for 15 minutes. Additional effects are antiinflammatory anesthetic, and bacteriostatic. Can cause a garliclike taste and odor on breath and skin for up to 72 h. Pregnancy category: C; PB: UK; t½: UK |
| flavoxate HCl (Urispas) | A: PO: 100–200 mg t.i.d. or q.i.d. | For urinary tract spasms. To be avoided by persons with glaucoma. Cautious use by older adults. Side effects include nausea, vomiting, dry mouth, drowsiness, blurred vision. Pregnancy category: B; PB: UK; t½: UK |
| oxybutynin Cl (Ditropan) | A: PO: 5 mg b.i.d. or t.i.d.Elderly: PO: 2.5-5 mg b.i.d.C: >5 y: PO: 5 mg b.i.d.C: 1–5 y: PO: 0.2 mg/kg b.i.d.-q.i.d. | For urinary tract spasms and overactive bladder. Contrain-dicated for persons with cardiac, renal, hepatic, and prostate problems. Side effects include drowsiness, blurred vision, and dry mouth. Pregnancy category: B; PB: UK; t½: 1–3 h |
| tolterodine tartrate (Detrol) | A: PO: 2 mg b.i.d.Decrease to 1 mg b.i.d. with liver or kidney dysfunction | To control overactive bladder by decreasing urinary frequency and urgency. Client with narrow-angle glaucoma should not take this drug. Dry mouth is common. Pregnancy category: C; PB: 96%; t½: 2-3.5 h |
| trospium chloride (Sanc-tura) | A: PO: 20 mg twice daily | To treat overactive bladder by action of a muscarinic-receptor antagonist. Pregnancy category: C; PB: UK; t½: 20 h |
| solifenacin succinate (VESI-care) | A: PO: 5 mg/d initially; then may be increased to 10 mg/d if tolerated | To treat overactive bladder by action of a muscarinic-receptor antagonist. Pregnancy category: C; PB: UK; t½: 45–68 h |
| darifenacin hydrobromide (Enablex) | A: PO: 7.5-15 mg daily | To treat overactive bladder by action of a muscarinic-receptor antagonist. Pregnancy category: C; PB: 98%; t½: 13–19 h |
| phenazopyridine HCl (Pyridium, Urodine) | A: PO: 100–200 mg t.i.d. p.c. × 2 dC: PO: 12 mg/kg in 3 divided dosesPregnancy category: B; PB: UK; t½: UK | For chronic cystitis to alleviate pain & burning sensation during urination. Urine will be reddish orange.Treats only symptoms, not underlying cause. Should not be used long-term for undiagnosed urinary tract pain.Can be taken concurrently with antibiotic |
Created by:
zoranrula@yahoo.com
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