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Pharm FINAL to know3
Pharm FINAL to know 3
Question | Answer |
---|---|
Laxative for hepatic coma | Lactulose; hyperosmotic |
Lubricant laxatives- ADR | ↓ the absorption of fat-soluble vitamins ADR- Skin rashes; Decreased absorption of vitamins; electrolyte imbalance |
Opioids- Narcotics | ADR-Diuresis, miosis, convulsions, N/V and respiratory depression, ↓ b/p, constipation, urinary retention, skin flushing, sweating, urticaria & pruritus Tx- OD- Narcan or Revex |
Opioid | withdrawal- Peak period: 1 to 3 days; Duration: 5 to 7 days Tx- Naltrexone, clonidine (Catapres) substitution, methadone substitution |
Alcohol Withdrawal | MILD-BP > 150/90 Pulse >110 beats/minute; Temp> 100° F; Insomnia; Tremors; Agitation MODERATE- BP 150/100-200/140 Pulse 110 -140 Temp100° -101° F SEVERE BP -150/100-200/ 140 Pulse 110-140 Temp 100°-101° F |
Alcohol Tx | Benzodiazepines are the treatment of choice- Diazepam (Valium), (Ativan) (Librium); also used- Antabuse, Acamprosate (newest tx) |
Drug-drug interactions with NSAIDS | aspirin↓ blood levels may ↓ effectiveness ↑ risk of bleeding with anticoagulants , thrombolytic agents , eptifibatide , tirofiban , cefotetan , cefoperazone , valproic acid , corticosteroids , clopidogrel , and ticlopidine |
Drug Drug interactions with NSAIDs con't | Probenecid↑ blood levels and may ↑ toxicity May ↑ risk of toxicity from methotrexate , antineoplastics , or radiation therapy Additive adverse GI side effects with aspirin , corticosteroids , alcohol , and other NSAIDs |
Drug Drug interactions with NSAIDs con't 3 | May ↑ serum levels and risk of toxicity from lithium ↑ risk of adverse renal effects with cyclosporine or chronic use of acetaminophen May ↓ response to ACE Inhibitors , angiotensin II antagonists, or furosemide |
Drug Drug interactions with NSAIDs con't 4 | May ↑ risk of hypoglycemia with insulin or oral hypoglycemic agents Oral potassium supplements may ↑ GI adverse effects |
salicylate intoxication adults | tinnitus and hearing loss; Also vision loss, fever, lethargy, confusion, n/v. Severe: resp. depression and coma |
salicylate intoxication Children | hyperventilation → respiratory alkalosis; CNS effects (lethargy or excitability); Metabolic acidosis & seizures; Febrile, N/V |
Salicylate | Overdose - serum levels exceed 40 to 60 mg/dL Tx: d/c drug, gastric lavage w/ charcoal, F & E replacement , IV NaHCO3 (↓ met. Acidosis), supportive symptoms & possibly dialysis. NO antidote |
Quinolones – ADR | depression,restlessness, insomnia, convulsions-, thrush, ↑AST & ALT, flatulence, heartburn, dysphagia, colitiis Rash, pruritus, urticaria, flushing, photosensitivity, blurred vision, tinnitus, ***ruptured tendons & tendonitis |
DOC for anxiety | Benzodiazepines |
drug classifications for preventing and treating ulcers | Aluminum salts; Magnesium salts; Calcium salts; Sodium bicarbonate; Proton Pump Inhibitors, H2 Antagonists |
MOA of ulcer tx drugs | Block histamine at the (H2) receptors of parietal cells → ↓ production of H+ ions → ↓ production of HCl |