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Potassium Sparing Diuretics
Question | Answer |
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Potassium Sparing Diuretics: Na-channel blockers (Often used in combination with other diuretics.) MECHANISM OF ACTION: | Inhibition of Na channel in the collecting duct. Results in excretion of Na and retention of K. |
Potassium Sparing Diuretics: Aldosterone Antagonists Mechanism of action: | Aldosterone receptors located in the collecting ducts. Activation of these receptors leads to: Activation of inactive Na channels Stimulation of the production of more Na channels. |
Potassium Sparing Diuretics: Aldosterone Antagonists (Mechanism cont'd) | Competitive inhibition of these receptors leads to increased Na excretion. |
Kinetics: | Good oral absorption. Liver metabolism. |
Adverse Effects: | Hyperkalemia. Hypotension. Nausea/vomiting. Weakness. Headache. Fatigue. Gynecomastia - spironolactone. |
Cautions | Renal insufficiency Diabetes Those on ACE inhibitors, NSAIDS, or K supplements. |
Names | Na channel blockers: Triamterene (Dyrenium) Amiloride (Midamor) Aldosterone antagonists: Spironolactone (Aldactone) Eplerenone (Inspra) |
Diuretic combinations | Hydrochlorothiazide/amiloride (Moduretic) Hydrochlorothiazide/spironolactone (Aldactazide, Spirozide) Hydrochlorothiazide/triamterene (Dyazide, Maxzide) |