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Lippincott Ch. 40
Immunosuppressants
Question | Answer |
---|---|
cyclosporin | binds to cyclophilin forming a complex that binds to calcenurin |
sirolimus | binds to mTOR interfering with signal 3 |
tacrolimus | binds to FKBP-12 |
azathioprine | forms 6-MP then thioinosinic acid |
mycophenolate mofetil | forms MPA, which inhibits IMP |
mycophenolate sodium | created to minimize the GI effects associated with MMF |
alemtuzumab | directed CD52 |
antithymocyte globulins | Ab against thymocytes |
basiliximab | binds to CD25 |
daclizumab | binds to CD25 but more potent |
muromonab-CD3 | binds to CD3 |
methylprednisolone | corticosteroid used for transplantation |
prednisolone | corticosteroid used for autoimmune conditions |
prednisone | corticosteroid used for transplantation or autoimmune conditions |