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Heiman.pharm.vascev

Cholesterol Screening and drugs

QuestionAnswer
LDL Cholesterol – Primary Target of Therapy <100 Optiimal 100-129: Near optimal/above optimal 130-159: Borderline high 160-189: High >190: Very high
Total Cholesterol <200: Desirable 200-239: Borderline High >240: High
HDL Cholesterol <40: low >60: High
Risk Factors That Modify LDL Goals Cigarette smoking Diabetes Hypertension (BP ≥ 140/90 mmHg or on antihypertensive medication)
Risk Factors That Modify LDL Goals Family history of premature CHD (CHD in male first degree relative < 55 years; CHD in female first degree relative < 65 years) Age (men ≥ 45 years; women ≥ 55 years)
CHD or CHD Risk Equivalents LDL Goal:<100 LDL level to TLC:>100 LDL to initiate drug therapy:>100
2+ Risk Factors LDL Goal:<130 LDL level to TLC:>130 LDL to initiate drug therapy:≥ 130 mg/dL if 10-yr risk > 10%, ≥160 if 10-yr risk <10%
0-1 Risk Factor LDL Goal:<160 LDL level to TLC: >160 LDL to initiate drug therapy:>190
HMG-CoA Reductase Inhibitors HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate in the liver Mevalonate is a cholesterol precursor These drugs are reversible, competitive inhibitors of this enzyme This results in the inhibition of cholesterol synthesis
Created by: DianaB
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