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Heiman.pharm.vascev5
Selective Cholesterol Absorption Inhibitor
Question | Answer |
---|---|
Mechanism | Acts on the brush border of intestinal epithelial cells to selectively inhibits the absorption of cholesterol from dietary and biliary sources |
Effects | Decreased LDL Decreased triglycerides Increased HDL |
Kinetics | Little oral absorption Enterohepatic recirculation Metabolized in liver and small intestine to active drug Eliminated in feces |
Cautions | Not recommended with hepatic insufficiency |
Adverse Effects | Fatigue Cough Abdominal pain Diarrhea Dizziness |
Drug Interactions | Fibric acid derivatives Increased levels of ezetimibe Bile acid sequestrants Decreased ezetimibe levels Cyclosporine Increased ezetimibe levels |
Names | Ezetimibe (Zetia) Vytorin (ezetimibe + simvastatin) |