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Heiman.pharm.vascev9
Clopidogrel
Question | Answer |
---|---|
Mechanism | Inhibits the binding of adenosine diphosphate to the receptor on the platelets preventing the activation of the glycoprotein IIb/IIIa complex This complex promotes platelet aggregation Inhibition is irreversible |
Ticlopidine (Ticlid) | Mechanism the same as clopidogrel Not used very much any more due to the possibility of life-threatening agranulocytosis |
Kinetics | About 50% bioavailable Hepatic metabolism Renal clearance |
Adverse Effects | Bleeding TTP – rare Nausea Diarrhea Rash Fatigue Palpitations Chest pain |
Cautions | Liver disease Other anticoagulant / antiplatelet drugs |