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Heiman.pharm.vasev9
Dipyridamole
Question | Answer |
---|---|
Mechanism | Causes an increase in adenosine levels producing vasodilation Inhibition of phosphodiesterase which decrease levels of cAMP Low cAMP is associated with decreased platelet adhesion |
Kinetics | Bioavailability 33 – 67 % Liver metabolism, CYP450 Renal Excretion |
Adverse Effects | Bleeding Hypotension Dizziness Nausea Flushing Rash |
Cautions | Use with caution when taking other blood thinners |
Names | Persantine Oral IV Used for exercise tolerance testing Aggrenox Sustained release in combination with aspirin |