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Heiman.pharm.vasc12
Low Molecular Weight Heparins (LMWHs)
Question | Answer |
---|---|
Mechanism | Inhibition of clot formation higher up the clotting cascade |
Kinetics | Not absorbed orally, given SC Relatively long half-life Extensive renal clearance Dosage adjustment in renal disease needed |
Adverse Effects | Bleeding Thrombocytopenia Pulmonary edema Fever Peripheral edema |
Cautions | Use cautiously with other blood thinners No need to follow aPTT Can get Anti-Xa levels but it is not routine practice Protamine cannot be used for overdosage |
Names | Enoxaparin (Lovenox) Dalteparin (Fragmin) Tinzaparin (Innohep) Fondaparinux (Arixtra) Not technically a LMWH Direct Anti-Xa inhibitor |