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Pharm - Thyroid
Drugs for Tx, Patho, AP
Question | Answer |
---|---|
Condition: Dwarfism Severe mental retardation | Cretinism (Hypothyroidism) |
Condition: Slowed body metabolism Slurred speech Bradycardia weight gain Low body temperature Intolerance to cold | Myxedema (Hypothyroidism) |
Blood tests used to Dx thyroid problems specifically Hypothyroidism? | Serum levels of circulating T3 and T4 hormones |
Drug od choice used to Tx hypothyroidism by increasing T4 hormone? | Synthetic levothyroxine |
What is the brand name for Synthetic levothyroxine? | Synthroid, Levoxyl |
Side effects of Synthetic levothyroxine(Synthroid)? | Hyperthyroidism Dose related May occur 1 to 3 weeks after changes in therapy |
Drug interactions that may cause concern for Synthetic levothyroxine? | Warfarin Digoxin Estrogens Diabetes medications |
Some clinical Signs/Symptoms of Hyperthyroidism? | Rapid, bounding pulse (even sleeping) Cardiac enlargement Palpitations Dysrhythmias Nervous Easily agitated Tremors Low grade fever Hyperactive reflexes Insomnia Intol. heat Warm, flushed moist skin, Sweating |
Different treatments for Hyperthyroidism? | Subtotal thyroidectomy Radioactive iodine Antithyroid medications |
Destroys the hyperactive thyroid tissue, with essentially no damage to other tissues in the body | Iodine – 131 |
Radioactive isotope of iodine Absorbed into thyroid in high concentrations | Iodine – 131 |
Block synthesis of T3 and T4 in the thyroid gland Do not destroy what is already there Few days to 3 weeks before symptoms improve | Antithyroid agents |
Prophlthiouracil (PTU, Propacil) Methimazole (Tapazole) What class of drugs are these? | Antithyroid Agents |
Some side effects of antithyroids? | Purpuric, maculopapular rash, Headaches, loss of taste, bone marrow suppression, hepatotoxicity |