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cholinolytics
cholinolytic drugs
Question | Answer |
---|---|
Atropine kinetics | tertiary amine kinetic:eliminated via metabolism in liver and renal excretion (1/2 life 2 hours), long duration in eye |
Atropine clinical uses | clinical uses: Opthalmic uses opthalmic: mydriasis and cycloplegia (fundus exams, break symechiae)and othersACLS: stimulate heart rate insecticide and mushroom poisoning GI: decrease GI motility, Lungs: reduce airway secretions. |
Atropine toxicity | decreased sweating and lacrimation, elevation of BT,: tachycardia, constipation, dry mouth, and blurred vision, mydriasis. CNS: sedation, amnesia, delirium, hrt arrhythmias, and cutaneous vasodila; contra: in glaucoma, children and prostatic hypeplasia |
Scopolamine, cyclopentolate, tropicamide clinical uses: | Opthalmic uses opthalmic: mydriasis and cycloplegia (fundus exams, break symechiae)and others |
Scopolamine kinetics | kinetics:faster onset than atropine |
other scopolamine uses: | uses: motion sickness tertiary amine |
cyclopentolate and tropicamide kinetics | C:medium duration T: short duration |
Oxybutynin, darifenacin, solifenacin, tolterdine clinical uses: | clinical uses: Urinary (urge incontinece, bladder spasms) tertiary amine (eye and CNS effects), lipid soluble, well distributed in CNS |
Dicyclomin clinical uses: | GU (irritable bowel syndrome, minor diarrhea, block muscarinic effects in periphery) tertiary amine: (eye and CNS effects), lipid soluble, well distributed in CNS |
parkinson's disease drugs: | Benztropine, Biperiden, Orphenadrine, procyclidine, trihexyphenidyl |
Quartenary amines: | Glycopyrrolate, Mepenzolate, Methscopolamine,Tridihexethyl, Clindinium, Trospium,PropanthelineI, pratropium, Tiotropium |
Glycopyrrolate, Mepenzolate, Methscopolamine, Tridihexethyl,Clindinium,Trospium,Propantheline clinical uses: | GU (irritable bowel syndrome, minor diarrhea, block muscarinic effects in periphery |
Ipratropium, Tiotropium clinical uses: | repiratory( asthma and COPD) |
nicotinic blockers/ ganglion blockers | Hexamethonium, Trimethaphan, Mecamylamine |
nicotinic blockers uses: | Hypertensive emergencies, induce hypotension |