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IOS 11 Exam 4
Pharmacotherapy of HIV infection
Question | Answer |
---|---|
What is the prefered 1NNRTI + 2NRTI combinations | Efavarinz + either Truvada or Combivir |
What is the 2nd line 1NNRTI + 2NRTI combinations | Nevirapine + Epizicom or didanosine + (emtricitabine or lamivudine) |
What is the 1st Line 1-2PI +2NRTI therapy | Fos=Amp/r+ (Truvada or Combivir) orAtazanavir/r+(Truvada or Combivir) or Kaletra + (Truvada or Combivir) |
2nd Line 1-2PI +2NRTI therapy | 1. Fos=Amp/r+ abacavir/lamivudine or didanosine +(emtricitabine or lamivudine) or 2. Atazanavir/r+ abacavir/lamivudine or didanosine +(emtricitabine or lamivudine) or 3. Kaletra + abacavir/lamivudine or didanosine +(emtricitabine or lamivudine) |
Atazanavir +Indininavir | Not recommended due to hyperbilirubina |
Didanosine +stavudine | Not recommended due to Additive mitochondrial toxcity=NRTIs |
Zidovudine +stavudine | Antagonsims -both thymidine analogs |
Efavarinz +rifampin | 25% decrease AUC of Efavarinz if >60 increase dose to 800mg if <60mg Leave at 600mg Remember the option of abacivir +lamivudine/zidovidune (Combivir) can be used no DI ! |