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Adrenergic Nerv Syst

www.pharmteacher.com Adrenergic Nerv Syst Receptor, Location, & Effect

What receptor is found here?Mostly this type of receptorWhat happens?Physiological ResponsePhysiological Response
For best results click each card 6 times to see ALL the related material. First you will see the organ or tissue. Click to see the type of receptor most prevalent there. You will be asked what happens when those receptors are stimulated. Next, you will be asked what happens when those receptors are blocked. Sometimes, additional info is also given.
Lungs (Bronchioles) mostly B2 What happens when these receptors are stimulated? BronchoDILATION... The body needs MORE oxygen in a fight/flight situation. E.g. albuterol is a B2 agonist What happens when these receptors are blocked? BronchoCONSTRICTION... Chest tightness, difficulty breathing.
Vasculature of Skin and Mucous Membranes mostly A1 What happens when these receptors are stimulated? VasoCONSTRICTION... Increased BP. Why? Body wants to shunt blood away from nonessential areas (e.g. skin) and to heart & muscles. Skin is the largest body organ thus LOTS of vasoconstriction occurs. What happens when these receptors are blocked? VasoDILATION... Reduced BP. E.g. alpha 1 blockers reduce BP.
Liver mostly B2 What happens when these receptors are stimulated? Glycogenolysis... Increased liver production of glucose. The body need energy in a fight/flight situation. What happens when these receptors are blocked? Liver will be less able to produce glucose. Can prolong episodes of hypoglycemia so be careful in a patient with diabetes.
Uterus mostly B2 What happens when these receptors are stimulated? Reduced uterine contractions... Why? You don't want to go into labor during a fight/flight situation, right? What happens when these receptors are blocked? May stimulate uterine contractions... This could induce early labor in a pregnant woman.
Urinary Tract (Bladder Muscle and Urinary Sphincter) mostly A1 What happens when these receptors are stimulated? Urinary retention... Difficulty urinating. You don't want to have to stop and pee in a flight/fight situation. What happens when these receptors are blocked? Urinary incontinence... Loss of bladder control.
Presynaptic Nerve Terminals mostly A2 What happens when these receptors are stimulated? Reduction of further norepinephrine release... This is how the body "shuts off" the adrenaline output. E.g. alpha2 agonists lower BP. What happens when these receptors are blocked? Increased release of norepinephrine
Pupil of the Eye mostly A1 What happens when these receptors are stimulated? Mydriasis (pupil dilation)... Not useful to know medically, but when you are sexually aroused, you release adrenaline and your pupils dilate. What happens when these receptors are blocked? Miosis (pupil constriction)
Heart mostly B1 What happens when these receptors are stimulated? Increased HR (tachycardia) and increased force of cardiac contraction (positive inotrope) What happens when these receptors are blocked? Decreased HR (bradycardia) and decreased force of cardiac contraction (negative inotrope)
Vasculature of Skeletal Muscle mostly B2 What happens when these receptors are stimulated? VasoDILATION... Why? We need to Increase blood flow to muscles in fight/flight situation. Yes this could decrease BP but remember if A1 receptors are also being stimulated, overall BP will go up. (Body has more skin than muscle) What happens when these receptors are blocked? VasoCONSTRICTION... Blood flow to muscles is reduced.
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