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Pharm test uno

Question?Answer
Bactrim MOA? Inhibits folic Acid synthesis
When would you not use opt. Aminoglycosides? Perferation of tempanic membrane
Which medication causes a "disulfiram like reaction" with alcohol? Metronidazole (Flagyl)
Metronidazaole (Flagyl) interferes with what system? CYP2C9 which also interacts with Warfarin
Side effect to Sulfamethoxazole/Trimethoprim? Bone Marrow Suppression (TMP="Treats Marrow Poorly")
Drug of choice for PJP/PCP? TMP/SMX (Bactrim)
2 side effects to Nitrofurantoin (Macrobid)? 1. Pulmonary toxicity (chronic use) 2. Peripheral neuropathy
What is Nitrofurantoin (Macrobid) used for? Treatment of UTI's
Rifampin side effects? 1. Turns fluids red 2. Hepatotoxicity
"R's" of Rifampin? RNA polymerase inhibitor Red urine/fluids Ramps or Revs up enzymes Rapid Resistance when used alone
Biggest side effect of Amp. B? Infusion reactions (why premedicate with NSAID or diphenhydramine)
How long to give Amp B? Over 4-6 hours to avoid side effects like chills, hypotension, and dysrhythmias
How do you give Amp B? Only compatable in D5%W, so flush lines, and give 250cc bolus before and after to keep hydrated.
Onychomycosis duration of tx? Fingernail= 6 weeks Toenail= 12 weeks (3 months)
Griseofulvin uses? Ringworm of the scalp or body, athletes foot, onychomycosis
Griseofulvin MOA? Fungistatic. Targets new skin where it binds to keratin to prevent new growth. NOT treat existing infection, which takes so long. ALSO binds to microtubules in mitotic spindle inhibiting mitosis. Preg Cat D/X!!
Which antifungal requires gastic acidity? Ketoconazole (Nizoral) & Itraconazole (Sporanox)
Griseofulvin Preg. Category? D/X! Limited to Microsporumnea spp., Trichophyton
B lactams MOA Inhibits cell wall synthesis
4 classes that treat Atypicals? Macrolides, Ketolides, Fluorquinolones, Tetracyclines
DOC Recurrent/Persistent Urethritis? Metronidazole 2gm x1+ E-mycin QID x7 days
DOC Candida? Intravaginal tx or Fluconazole 150mg x1 dose
DOC Trichomoniasis? Metronidazole 2gm POx1 OR "" 500mg BID x 7 days *Also screen for HIV; Inflammation ^ risk for HIV
DOC Bacterial Vaginosis? Matronidazole 500mg BID x 7 days OR "" 2g x1 dose OR "" Intravaginally QD x 5 days OR Clindamycin intravag. QHS x7 days
DOC Gonorrhea Pharynx? Ceftriaxone 125 IM x1 dose Ciprofloxacin 500mg x1 dose
DOC Gonnorrhea Cervix, Urethra, Rectum? Cefixime 400mg Ceftriaxone 125 IM Ofloxacin 400mg/Levofloxacin 250mg *ALT: Spectinomycin 2g IM x1 dose *Cephalosporin x1 dose *Quinolone x1 dose
DOC Syphilis? Benzathine PCN G IM x1
DOC Neurosyphilis? Aqueous crystalline PCN G
DOC Genital Herpes? Acyclovir 400mg TID Famciclovir 250mg TID Valacyclovir 1000mg BID
DOC Chancroid? Azithromycin 1gm PO Ceftraxone 250mg IM x1 Cepro 500mg BID x3 days E-mycin 500mg TID x7days
DOC Nongonococcal Urethritis? Azithromycin 1mg x1 dose Doxycycline 100mg DIB x7 days *Alt: E-mycin QID x 7days
DOC Chlamydia? Azithromycin 1mg x1 dose Doxycycline 100mg DIB x7 days *Alt: E-mycin QID x 7days
Created by: hdeis
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