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Histamine-2 Antagoni

Pharmacology

QuestionAnswer
Drugs used to treat ulcers Histamine 2 antagonists, Antacids, Proton pump inhibitors, Antipeptic agents, Prostaglandins
Action of H2 antagonists blocks the release of hydrocloric acid in response to gastrin
Action of Antacids neutralizes acid at the chemical level
Action of Proton Pump Inhibitors suppress the secretions of hydrocloric acid
Action of Antipeptic agents coat the injured area in the stomach to prevent further injury from acid
Action of Prostaglandins inhibit the secretion of gastrin and increase the secretions of the mucous lining of the stomach, providing a buffer
H2 Antagonists drugs cimetidine (Tagament), ranitidine (Zantac), famotidine (Pepcid), nizatidine (Axid)
G/B cimetidine Tagamet
cinetidine (Tagamet) 1st drug in the H2antagonists class to be developed, met/live, exc/urine, CPEBM, ava in O, P forms
G/B ranitidine Zantac
ranitidine (Zantac) longer acting and more potent then cinetidine, met/liver, exc/urine, ava in O, P forms, CPEBM, Not associated w/antiadrenergic adverse effects
G/B famotidine Pepcid
famotidine (Pepcid) much more potent than cinetidine and ranitidine, ava O, IV forms, met/liver, exc/urine CPEBM
G/B nizatidine Axid
nizatidine (Axid) newest drug in the H2 antagonists class, similar to ranitidine, IT DIFFERS FROM OTHERS, it is exc/kidneys, w/no 1st pass effect. Drug of choice for pt w/liver dysfunctions. ava in O form, CPEBM
CPEBM cross placenta enter breast milk
H2 antagonists---Therapeutic acations leads to reduction in gastric acid secretion and pepsin production. Used mainly for short term use to treat duodenal ulcer. Prophylaxis of stress induced ulcer. Treatment of gastroexophageal reflux. Promotes healing and decreases pain. Relief of hear
H2 antagonists--contraindications caution should be used during preg/lac, and w/hepatic or renal dysfuctions that could interfer with drug metabloism or excretion
H2 antagonists--adverse effects & drug/drug interactions AE of GI:diarrhea or constipation. CNS effects: dizziness or headace. Drug/drug---warfarin (anticoagulants), alcohol
Created by: jessinms
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